Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats
Joint Authors
Hernández-Fonseca, Juan P.
Viera, Ninoska
Rincón, Jaimar
Mosquera, Jesús
Carrizo, Edgardo
Pedreañez, Adriana
Arcaya, José L.
Source
Experimental Diabetes Research
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Autonomic and peripheral neuropathies are well-described complications in diabetes.
Diabetes mellitus is also associated to central nervous system damage.
This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical and structural abnormalities.
The purpose of this study was to investigate brain structural and ultrastructural changes in rats with streptozotocin-induced diabetes.
Cerebral cortex, hypothalamus, and cerebellum were obtained from controls and 8 weeks diabetic rats.
Light and electron microscope studies showed degenerative changes of neurons and glia, perivascular and mitochondrial swelling, disarrangement of myelin sheath, increased area of myelinated axons, presynaptic vesicle dispersion in swollen axonal boutoms, fragmentation of neurofilaments, and oligodendrocyte abnormalities.
In addition, depressive mood was observed in diabetic animals.
The brain morphological alterations observed in diabetic animals could be related to brain pathologic process leading to abnormal function, cellular death, and depressive behavioral.
American Psychological Association (APA)
Hernández-Fonseca, Juan P.& Rincón, Jaimar& Pedreañez, Adriana& Viera, Ninoska& Arcaya, José L.& Carrizo, Edgardo…[et al.]. 2009. Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats. Experimental Diabetes Research،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-464054
Modern Language Association (MLA)
Hernández-Fonseca, Juan P.…[et al.]. Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats. Experimental Diabetes Research No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-464054
American Medical Association (AMA)
Hernández-Fonseca, Juan P.& Rincón, Jaimar& Pedreañez, Adriana& Viera, Ninoska& Arcaya, José L.& Carrizo, Edgardo…[et al.]. Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats. Experimental Diabetes Research. 2009. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-464054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464054