Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging

Joint Authors

Poletti, Federica
Rimessi, Alessandro
Missiroli, Sonia
Bononi, Angela
Pinton, Paolo
Duszynski, Jerzy
Bonora, Massimo
Agnoletto, Chiara
De Marchi, Elena
Suski, Jan M.
Giorgi, Carlotta
Marchi, Saverio
Patergnani, Simone
Wieckowski, Mariusz R.

Source

Journal of Signal Transduction

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-11-14

Country of Publication

Egypt

No. of Pages

17

Main Subjects

Biology

Abstract EN

Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside mitochondria that can oxidize DNA, proteins, and lipids.

At physiological levels, ROS function as “redox messengers” in intracellular signalling and regulation, whereas excess ROS induce cell death by promoting the intrinsic apoptotic pathway.

Recent work has pointed to a further role of ROS in activation of autophagy and their importance in the regulation of aging.

This review will focus on mitochondria as producers and targets of ROS and will summarize different proteins that modulate the redox state of the cell.

Moreover, the involvement of ROS and mitochondria in different molecular pathways controlling lifespan will be reported, pointing out the role of ROS as a “balance of power,” directing the cell towards life or death.

American Psychological Association (APA)

Marchi, Saverio& Giorgi, Carlotta& Suski, Jan M.& Agnoletto, Chiara& Bononi, Angela& Bonora, Massimo…[et al.]. 2011. Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-464055

Modern Language Association (MLA)

Marchi, Saverio…[et al.]. Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging. Journal of Signal Transduction No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-464055

American Medical Association (AMA)

Marchi, Saverio& Giorgi, Carlotta& Suski, Jan M.& Agnoletto, Chiara& Bononi, Angela& Bonora, Massimo…[et al.]. Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging. Journal of Signal Transduction. 2011. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-464055

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-464055