N-Acetylcysteine Supplementation Controls Total Antioxidant Capacity, Creatine Kinase, Lactate, and Tumor Necrotic Factor-Alpha against Oxidative Stress Induced by Graded Exercise in Sedentary Men
Joint Authors
Pothongsunun, Prapas
Klaphajone, Jakkrit
Leelarungrayub, Donrawee
Khansuwan, Raphiphat
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Aim of this study was to evaluate the effects of short-term (7 days) N-acetylcysteine (NAC) at 1,200 mg daily supplementation on muscle fatigue, maximal oxygen uptake (VO2max), total antioxidant capacity (TAC), lactate, creatine kinase (CK), and tumor necrotic factor-alpha (TNF-α).
Twenty-nine sedentary men (13 controls; 16 in the supplement group) from a randomized control were included.
At before and after supplementation, fatigue index (FI) was evaluated in the quadriceps muscle, and performed a graded exercise treadmill test to induce oxidative stress, and as a measure of VO2max.
Blood samples were taken before exercise and 20 minutes after it at before and after supplementation, to determine TAC, CK, lactate, and TNF-α levels.
Results showed that FI and VO2max increased significantly in the supplement group.
After exercise decreased the levels of TAC and increased lactate, CK, and TNF-α of both groups at before supplementation.
After supplementation, lactate, CK, and TNF-α levels significantly increased and TAC decreased after exercise in the control group.
Whereas the TAC and lactate levels did not change significantly, but CK and TNF-α increased significantly in the supplement group.
Therefore, this results showed that NAC improved the muscle fatigue, VO2max, maintained TAC, controlled lactate production, but had no influence on CK and TNF-α.
American Psychological Association (APA)
Leelarungrayub, Donrawee& Khansuwan, Raphiphat& Pothongsunun, Prapas& Klaphajone, Jakkrit. 2011. N-Acetylcysteine Supplementation Controls Total Antioxidant Capacity, Creatine Kinase, Lactate, and Tumor Necrotic Factor-Alpha against Oxidative Stress Induced by Graded Exercise in Sedentary Men. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-464057
Modern Language Association (MLA)
Leelarungrayub, Donrawee…[et al.]. N-Acetylcysteine Supplementation Controls Total Antioxidant Capacity, Creatine Kinase, Lactate, and Tumor Necrotic Factor-Alpha against Oxidative Stress Induced by Graded Exercise in Sedentary Men. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-464057
American Medical Association (AMA)
Leelarungrayub, Donrawee& Khansuwan, Raphiphat& Pothongsunun, Prapas& Klaphajone, Jakkrit. N-Acetylcysteine Supplementation Controls Total Antioxidant Capacity, Creatine Kinase, Lactate, and Tumor Necrotic Factor-Alpha against Oxidative Stress Induced by Graded Exercise in Sedentary Men. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-464057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464057