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Effect of Prenatal Exposure to Lead on Estrogen Action in the Prepubertal Rat Uterus
Joint Authors
Gaete, Leonardo
Bustamante, Rodrigo
Tchernitchin, Andrei N.
Báez, Aracelly
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Lead is a widely spread environmental pollutant known to affect both male and female reproductive systems in humans and experimental animals and causes infertility and other adverse effects.
The present paper investigated the effects of prenatal exposure to lead on different parameters of estrogen stimulation in the uterus of the prepubertal rat.
In prenatally and perinatally exposed rats, estrogen-induced endometrial eosinophilia, endometrial stroma edema, and eosinophil migration towards the endometrium, and uterine luminal epithelial hypertrophy are enhanced while several other responses to estrogen appear unchanged.
These effects may contribute to decrease in fertility following prenatal exposure to lead.
The striking difference between most of these effects of prenatal exposure and the previously reported effects of chronic exposure to lead suggests that prenatal exposure to lead may neutralize the effects of chronic exposure to lead, providing partial protection of cell function against the adverse effects of chronic exposure to lead.
We propose that the mechanism involved, named imprinting or cell programming, persisted through evolution as a nongenetic adaptive mechanism to provide protection against long-term environmental variations that otherwise may cause the extinction of species not displaying this kind of adaptation.
American Psychological Association (APA)
Tchernitchin, Andrei N.& Gaete, Leonardo& Bustamante, Rodrigo& Báez, Aracelly. 2012. Effect of Prenatal Exposure to Lead on Estrogen Action in the Prepubertal Rat Uterus. ISRN Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-464062
Modern Language Association (MLA)
Tchernitchin, Andrei N.…[et al.]. Effect of Prenatal Exposure to Lead on Estrogen Action in the Prepubertal Rat Uterus. ISRN Obstetrics and Gynecology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-464062
American Medical Association (AMA)
Tchernitchin, Andrei N.& Gaete, Leonardo& Bustamante, Rodrigo& Báez, Aracelly. Effect of Prenatal Exposure to Lead on Estrogen Action in the Prepubertal Rat Uterus. ISRN Obstetrics and Gynecology. 2012. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-464062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464062