4-Methoxycarbonyl Curcumin : A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation
Joint Authors
Napolitano, Nicole
Johnson, Francis
Clemens, McKenzie
Golub, Lorne M.
Gu, Ying
Lee, Hsi-Ming
Zhang, Yu
Zhang, Yazhou
Sorsa, Timo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chronic inflammatory diseases such as periodontitis have been associated with increased risk for various medical conditions including diabetes and cardiovascular disease.
Endotoxin (lipopolysaccharide, LPS), derived from gram-negative periodonto-pathogens, can induce the local accumulation of mononuclear cells in the inflammatory lesion, increasing proinflammatory cytokines and matrix metalloproteinases (MMPs).
This ultimately results in the destruction of periodontal connective tissues including alveolar bone.
Curcumin is the principal dyestuff in the popular Indian spice turmeric and has significant regulatory effects on inflammatory mediators but is characterized by poor solubility and low bioactivity.
Recently, we developed a series of chemically modified curcumins (CMCs) with increased solubility and zinc-binding activity, while retaining, or further enhancing, their therapeutic effects.
In the current study, we demonstrate that a novel CMC (CMC 2.5: 4-methoxycarbonyl curcumin) has significant inhibitory effects, better than the parent compound curcumin, on proinflammatory cytokines and MMPs in in vitro, in cell culture, and in an animal model of periodontal inflammation.
The therapeutic potential of CMC 2.5 and its congeners may help to prevent tissue damage during various chronic inflammatory diseases including periodontitis and may reduce the risks of systemic diseases associated with this local disorder.
American Psychological Association (APA)
Gu, Ying& Lee, Hsi-Ming& Napolitano, Nicole& Clemens, McKenzie& Zhang, Yazhou& Sorsa, Timo…[et al.]. 2013. 4-Methoxycarbonyl Curcumin : A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-464068
Modern Language Association (MLA)
Gu, Ying…[et al.]. 4-Methoxycarbonyl Curcumin : A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-464068
American Medical Association (AMA)
Gu, Ying& Lee, Hsi-Ming& Napolitano, Nicole& Clemens, McKenzie& Zhang, Yazhou& Sorsa, Timo…[et al.]. 4-Methoxycarbonyl Curcumin : A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-464068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464068