4-Methoxycarbonyl Curcumin : A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation

Joint Authors

Napolitano, Nicole
Johnson, Francis
Clemens, McKenzie
Golub, Lorne M.
Gu, Ying
Lee, Hsi-Ming
Zhang, Yu
Zhang, Yazhou
Sorsa, Timo

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-12-24

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

Chronic inflammatory diseases such as periodontitis have been associated with increased risk for various medical conditions including diabetes and cardiovascular disease.

Endotoxin (lipopolysaccharide, LPS), derived from gram-negative periodonto-pathogens, can induce the local accumulation of mononuclear cells in the inflammatory lesion, increasing proinflammatory cytokines and matrix metalloproteinases (MMPs).

This ultimately results in the destruction of periodontal connective tissues including alveolar bone.

Curcumin is the principal dyestuff in the popular Indian spice turmeric and has significant regulatory effects on inflammatory mediators but is characterized by poor solubility and low bioactivity.

Recently, we developed a series of chemically modified curcumins (CMCs) with increased solubility and zinc-binding activity, while retaining, or further enhancing, their therapeutic effects.

In the current study, we demonstrate that a novel CMC (CMC 2.5: 4-methoxycarbonyl curcumin) has significant inhibitory effects, better than the parent compound curcumin, on proinflammatory cytokines and MMPs in in vitro, in cell culture, and in an animal model of periodontal inflammation.

The therapeutic potential of CMC 2.5 and its congeners may help to prevent tissue damage during various chronic inflammatory diseases including periodontitis and may reduce the risks of systemic diseases associated with this local disorder.

American Psychological Association (APA)

Gu, Ying& Lee, Hsi-Ming& Napolitano, Nicole& Clemens, McKenzie& Zhang, Yazhou& Sorsa, Timo…[et al.]. 2013. 4-Methoxycarbonyl Curcumin : A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-464068

Modern Language Association (MLA)

Gu, Ying…[et al.]. 4-Methoxycarbonyl Curcumin : A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-464068

American Medical Association (AMA)

Gu, Ying& Lee, Hsi-Ming& Napolitano, Nicole& Clemens, McKenzie& Zhang, Yazhou& Sorsa, Timo…[et al.]. 4-Methoxycarbonyl Curcumin : A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-464068

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-464068