Blockade of NR2A-Containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices
Joint Authors
Allyson, Julie
Massicotte, Guy
Auberson, Yves
Dontigny, Eve
Cyr, Michel
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Physiological activation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors has been proposed to play a key role in both neuronal cell function and dysfunction.
In the present study, we used selective NMDA receptor antagonists to investigate the involvement of NR2A and NR2B subunits in the modulatory effect of basal NMDA receptor activity on the phosphorylation of Tau proteins.
We observed, in acute hippocampal slice preparations, that blockade of NR2A-containing NMDA receptors by the NR2A antagonist NVP-AAM077 provoked the hyperphosphorylation of a residue located in the proline-rich domain of Tau (i.e., Ser199).
This effect seemed to be Ser199 specific as there was no increase in phosphorylation at Ser262 and Ser409 residues located in the microtubule-binding and C-terminal domains of Tau proteins, respectively.
From a mechanistic perspective, our study revealed that blockade of NR2A-containing receptors influences Tau phosphorylation probably by increasing calcium influx into neurons, which seems to rely on accumulation of new NR1/NR2B receptors in neuronal membranes and could involve the cyclin-dependent kinase 5 pathway.
American Psychological Association (APA)
Allyson, Julie& Dontigny, Eve& Auberson, Yves& Cyr, Michel& Massicotte, Guy. 2010. Blockade of NR2A-Containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices. Neural Plasticity،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-464090
Modern Language Association (MLA)
Allyson, Julie…[et al.]. Blockade of NR2A-Containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices. Neural Plasticity No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-464090
American Medical Association (AMA)
Allyson, Julie& Dontigny, Eve& Auberson, Yves& Cyr, Michel& Massicotte, Guy. Blockade of NR2A-Containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices. Neural Plasticity. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-464090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464090