In Situ Evaluation of Fludarabine-DNA Interaction Using a DNA-Electrochemical Biosensor
Joint Authors
Oliveira-Brett, Ana Maria
Eda Satana, H.
Source
International Journal of Electrochemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Fludarabine, 9-β-D-arabinosyl-2-fluoroadenine, the nucleoside analog, represents a highly effective treatment for hairy cell leukemia.
The electrochemical behaviour of fludarabine is an irreversible diffusion controlled oxidation mechanism and was investigated at a glassy carbon electrode in different supporting electrolytes using cyclic, differential pulse, and square wave voltammetry.
The diffusion coefficient of fludarabine was calculated to be DFLU=1.71×10−6 cm2 s-1 in pH 7.0 0.1 M phosphate buffer.
The oxidation mechanism of fludarabine occurs with the transfer of one proton and one electron and the formation of a hydroxylated species.
The interaction of fludarabine with DNA was investigated, by differential pulse voltammetry, in incubated solutions and using dsDNA- and polyhomonucleotides-, poly[G] and poly[A], electrochemical biosensors.
The results showed that fludarabine interacts with DNA causing changes in the DNA structure.
American Psychological Association (APA)
Eda Satana, H.& Oliveira-Brett, Ana Maria. 2011. In Situ Evaluation of Fludarabine-DNA Interaction Using a DNA-Electrochemical Biosensor. International Journal of Electrochemistry،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-464101
Modern Language Association (MLA)
Eda Satana, H.& Oliveira-Brett, Ana Maria. In Situ Evaluation of Fludarabine-DNA Interaction Using a DNA-Electrochemical Biosensor. International Journal of Electrochemistry No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-464101
American Medical Association (AMA)
Eda Satana, H.& Oliveira-Brett, Ana Maria. In Situ Evaluation of Fludarabine-DNA Interaction Using a DNA-Electrochemical Biosensor. International Journal of Electrochemistry. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-464101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464101