Inflammatory Regulation Effect and Action Mechanism of Anti-Inflammatory Effective Parts of Housefly (Musca domestica) Larvae on Atherosclerosis
Joint Authors
Zhu, Jia Yong
Xu, Yin Ye
Lu, Xue Mei
Jin, Xiao Bao
Liu, Wen Bin
Chu, Fu Jiang
Li, Xiao Bo
Ma, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The protein-enriched extracts of housefly larvae were segregated by gel-filtration chromatography (GFC) and then anti-inflammatory activity screening in RAW264.7 (induced by LPS) was carried out.
After acquire the anti-inflammatory effective parts, its anti-atherosclerotic properties in vivo were then evaluated.
Results showed that the anti-inflammatory effective parts of housefly larvae were low-molecular-weight parts.
After treated with the effective parts oral gavaged for 4 weeks, the atherosclerotic lesions of the mouse were significantly decreased.
The inflammatory and lipid parameters were also reduced (except HDL which was increased).
Western blot analysis demonstrated that the effective parts exerted potent inhibitory effect on expression of p65 in nucleus and cytoplasm.
The results of immunofluorescence microscopy analysis also showed that the expressions of p65 both in cytoplasm and nucleus were significantly reduced.
The hypothesis that the anti-inflammatory effective parts of housefly larvae possessed anti-atherosclerosis activity in mouse and the possible mechanism could be associated with the inhibition of expression and nuclear transfer of NF-κB p65 could be derived.
American Psychological Association (APA)
Chu, Fu Jiang& Jin, Xiao Bao& Xu, Yin Ye& Ma, Yan& Li, Xiao Bo& Lu, Xue Mei…[et al.]. 2013. Inflammatory Regulation Effect and Action Mechanism of Anti-Inflammatory Effective Parts of Housefly (Musca domestica) Larvae on Atherosclerosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-464103
Modern Language Association (MLA)
Chu, Fu Jiang…[et al.]. Inflammatory Regulation Effect and Action Mechanism of Anti-Inflammatory Effective Parts of Housefly (Musca domestica) Larvae on Atherosclerosis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-464103
American Medical Association (AMA)
Chu, Fu Jiang& Jin, Xiao Bao& Xu, Yin Ye& Ma, Yan& Li, Xiao Bo& Lu, Xue Mei…[et al.]. Inflammatory Regulation Effect and Action Mechanism of Anti-Inflammatory Effective Parts of Housefly (Musca domestica) Larvae on Atherosclerosis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-464103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464103