Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs
Joint Authors
Zhang, Tianmin
Xu, Wei
Ling, Peixue
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Oral administration is the most commonly used and readily accepted form of drug delivery; however, it is find that many drugs are difficult to attain enough bioavailability when administered via this route.
Polymeric micelles (PMs) can overcome some limitations of the oral delivery acting as carriers able to enhance drug absorption, by providing (1) protection of the loaded drug from the harsh environment of the GI tract, (2) release of the drug in a controlled manner at target sites, (3) prolongation of the residence time in the gut by mucoadhesion, and (4) inhibition of efflux pumps to improve the drug accumulation.
To explain the mechanisms for enhancement of oral bioavailability, we discussed the special stability of PMs, the controlled release properties of pH-sensitive PMs, the prolongation of residence time with mucoadhesive PMs, and the P-gp inhibitors commonly used in PMs, respectively.
The primary purpose of this paper is to illustrate the potential of PMs for delivery of poorly water-soluble drugs with bioavailability being well maintained.
American Psychological Association (APA)
Xu, Wei& Ling, Peixue& Zhang, Tianmin. 2013. Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs. Journal of Drug Delivery،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-464112
Modern Language Association (MLA)
Xu, Wei…[et al.]. Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs. Journal of Drug Delivery No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-464112
American Medical Association (AMA)
Xu, Wei& Ling, Peixue& Zhang, Tianmin. Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs. Journal of Drug Delivery. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-464112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464112