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The Effect of Cotrimoxazole Prophylactic Treatment on Malaria, Birth Outcomes, and Postpartum CD4 Count in HIV-Infected Women
Joint Authors
Van Rie, Annelies
Kayira, Dumbani
King, Caroline C.
van der Horst, Charles
Ellington, Sascha
Kacheche, Zebrone
Dow, Anna
Chome, Nelecy
Chasela, Charles
Turner, Abigail Norris
Jamieson, Denise J.
Hudgens, Michael G.
Kourtis, Athena P.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Limited data exist on cotrimoxazole prophylactic treatment (CPT) in pregnant women, including protection against malaria versus standard intermittent preventive therapy with sulfadoxine-pyrimethamine (IPTp).
Methods.
Using observational data we examined the effect of CPT in HIV-infected pregnant women on malaria during pregnancy, low birth weight and preterm birth using proportional hazards, logistic, and log binomial regression, respectively.
We used linear regression to assess effect of CPT on CD4 count.
Results.
Data from 468 CPT-exposed and 768 CPT-unexposed women were analyzed.
CPT was associated with protection against malaria versus IPTp (hazard ratio: 0.35, 95% Confidence Interval (CI): 0.20, 0.60).
After adjustment for time period this effect was not statistically significant (adjusted hazard ratio: 0.66, 95% CI: 0.28, 1.52).
Among women receiving and not receiving CPT, rates of low birth weight (7.1% versus 7.6%) and preterm birth (23.5% versus 23.6%) were similar.
CPT was associated with lower CD4 counts 24 weeks postpartum in women receiving (−77.6 cells/μL, 95% CI: −125.2, −30.1) and not receiving antiretrovirals (−33.7 cells/μL, 95% CI: −58.6, −8.8).
Conclusions.
Compared to IPTp, CPT provided comparable protection against malaria in HIV-infected pregnant women and against preterm birth or low birth weight.
Possible implications of CPT-associated lower CD4 postpartum warrant further examination.
American Psychological Association (APA)
Dow, Anna& Kayira, Dumbani& Hudgens, Michael G.& Van Rie, Annelies& King, Caroline C.& Ellington, Sascha…[et al.]. 2013. The Effect of Cotrimoxazole Prophylactic Treatment on Malaria, Birth Outcomes, and Postpartum CD4 Count in HIV-Infected Women. Infectious Diseases in Obstetrics and Gynecology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-464158
Modern Language Association (MLA)
Dow, Anna…[et al.]. The Effect of Cotrimoxazole Prophylactic Treatment on Malaria, Birth Outcomes, and Postpartum CD4 Count in HIV-Infected Women. Infectious Diseases in Obstetrics and Gynecology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-464158
American Medical Association (AMA)
Dow, Anna& Kayira, Dumbani& Hudgens, Michael G.& Van Rie, Annelies& King, Caroline C.& Ellington, Sascha…[et al.]. The Effect of Cotrimoxazole Prophylactic Treatment on Malaria, Birth Outcomes, and Postpartum CD4 Count in HIV-Infected Women. Infectious Diseases in Obstetrics and Gynecology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-464158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464158