Correlation of Increased Blood Levels of GITR and GITRL with Disease Severity in Patients with Primary Sjögren’s Syndrome
Joint Authors
Feng, Xiaoke
Tan, Wenfeng
Gu, Lei
Lv, Chengyin
Sun, Xiaoxuan
Gan, Xiaoxia
Zhang, Miaojia
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) is a type I transmembrane protein belonging to the TNFR superfamily.
After activated by its ligand GITRL, GITR could influence the activity of effector and regulatory T cells, participating in the development of several autoimmune and inflammatory diseases included rheumatoid arthritis and autoimmune thyroid disease.
We previously reported that serum GITRL levels are increased in systemic lupus erythematosus (SLE) patients compared with healthy controls (HC).
Here, we tested serum soluble GITR (sGITR) and GITRL levels in 41 primary Sjögren’s syndrome (pSS) patients and 29 HC by ELISA and correlated sGITR and GITRL levels with clinical and laboratory variables.
GITR and GITRL expression in labial salivary glands was detected by immunohistochemistry.
pSS patients had significantly increased serum levels of sGITR and GITRL compared with controls (GITR: 5.66 ± 3.56 ng/mL versus 0.50 ± 0.31 ng/mL; P<0.0001; GITRL: 6.17 ± 7.10 ng/mL versus 0.36 ± 0.28 ng/mL; P<0.0001).
Serum sGITR and GITRL levels were positively correlated with IgG (GITRL: r=0.6084, P<0.0001; sGITR: r=0.6820, P<0.0001) and ESR (GITRL: r=0.8315,P<0.0001; sGITR: r=0.7448, P<0.0001).
Moreover, GITR and GITRL are readily detected in the lymphocytic foci and periductal areas of the LSGs.
In contrast, the LSGs of HC subjects did not express GITR or GITRL.
Our findings indicate the possible involvement of GITR-GITRL pathway in the pathogenesis of pSS.
Further studies may facilitate the development of targeting this molecule pathway for the treatment of pSS.
American Psychological Association (APA)
Gan, Xiaoxia& Feng, Xiaoke& Gu, Lei& Tan, Wenfeng& Sun, Xiaoxuan& Lv, Chengyin…[et al.]. 2013. Correlation of Increased Blood Levels of GITR and GITRL with Disease Severity in Patients with Primary Sjögren’s Syndrome. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-464162
Modern Language Association (MLA)
Gan, Xiaoxia…[et al.]. Correlation of Increased Blood Levels of GITR and GITRL with Disease Severity in Patients with Primary Sjögren’s Syndrome. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-464162
American Medical Association (AMA)
Gan, Xiaoxia& Feng, Xiaoke& Gu, Lei& Tan, Wenfeng& Sun, Xiaoxuan& Lv, Chengyin…[et al.]. Correlation of Increased Blood Levels of GITR and GITRL with Disease Severity in Patients with Primary Sjögren’s Syndrome. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-464162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464162