The Relationship between H. pylori Infection and Osteoporosis in Japan
Joint Authors
Asaoka, Daisuke
Shimada, Yuji
Sasaki, Hitoshi
Yoshizawa, Takashi
Hojo, Mariko
Nagahara, Akihito
Osada, Taro
Watanabe, Sumio
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background and Objective.
H.
pylori infection causes a chronic inflammation in the gastric mucosa.
However, this local inflammation may result in extra-digestive conditions.
Our aim is to investigate the relationship between H.
pylori infection and osteoporosis in Japan.
Methods.
This cross-sectional study was conducted among outpatients at the Juntendo University Hospital between 2008 and 2014.
Participants for patient profile, H.
pylori infection status, comorbidity, internal medical therapies, lumbar dual-energy X-ray absorptiometry (DXA), and bone turnover marker were collected and upper gastrointestinal endoscopy for reflux esophagitis, hiatal hernia, peptic ulcer disease (PUD), and endoscopic gastric mucosal atrophy (EGA) was performed.
The diagnosis of osteoporosis was performed in accordance with the Japanese criteria.
We investigated risk factors of osteoporosis.
Results.
Of the eligible 200 study subjects, 41 cases were of osteoporosis.
Bivariate analysis showed that age, being female, BMI, alcohol, smoking, H.
pylori, bone-specific ALP, PUD, and EGA were related to osteoporosis.
Multivariate analysis showed that age (OR 1.13; 95%CI 1.07–1.20), being female (OR 4.77; 95%CI 1.78–12.77), BMI (OR 0.79; 95%CI 0.68–0.92), H.
pylori (OR 5.33; 95%CI 1.73–16.42), and PUD (OR 4.98; 95%CI 1.51–16.45) were related to osteoporosis.
Conclusions.
H.
pylori infection may be a risk factor of osteoporosis in Japan.
American Psychological Association (APA)
Asaoka, Daisuke& Nagahara, Akihito& Hojo, Mariko& Sasaki, Hitoshi& Shimada, Yuji& Yoshizawa, Takashi…[et al.]. 2014. The Relationship between H. pylori Infection and Osteoporosis in Japan. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-464165
Modern Language Association (MLA)
Asaoka, Daisuke…[et al.]. The Relationship between H. pylori Infection and Osteoporosis in Japan. Gastroenterology Research and Practice No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-464165
American Medical Association (AMA)
Asaoka, Daisuke& Nagahara, Akihito& Hojo, Mariko& Sasaki, Hitoshi& Shimada, Yuji& Yoshizawa, Takashi…[et al.]. The Relationship between H. pylori Infection and Osteoporosis in Japan. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-464165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464165