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Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma
Joint Authors
Tam, John Kit Chung
Tran, Thai
Teoh, Chun Ming
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Airway hyperresponsiveness (AHR) is one of the cardinal features of asthma.
Contraction of airway smooth muscle (ASM) cells that line the airway wall is thought to influence aspects of AHR, resulting in excessive narrowing or occlusion of the airway.
ASM contraction is primarily controlled by agonists that bind G protein-coupled receptor (GPCR), which are expressed on ASM.
Integrins also play a role in regulating ASM contraction signaling.
As therapies for asthma are based on symptom relief, better understanding of the crosstalk between GPCRs and integrins holds good promise for the design of more effective therapies that target the underlying cellular and molecular mechanism that governs AHR.
In this paper, we will review current knowledge about integrins and GPCRs in their regulation of ASM contraction signaling and discuss the emerging concept of crosstalk between the two and the implication of this crosstalk on the development of agents that target AHR.
American Psychological Association (APA)
Teoh, Chun Ming& Tam, John Kit Chung& Tran, Thai. 2012. Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma. Journal of Allergy،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-464214
Modern Language Association (MLA)
Teoh, Chun Ming…[et al.]. Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma. Journal of Allergy No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-464214
American Medical Association (AMA)
Teoh, Chun Ming& Tam, John Kit Chung& Tran, Thai. Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-464214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464214