Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract
Joint Authors
Tsia, Yu-Ting
Hsu, Chih-Ping
Huang, Chiu-Chen
Lin, Yi-Hsien
Chou, Jyh-Ching
Su, Jhih-Rou
Lin, Chih-Cheng
Chung, Yuan-Chiang
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The Litchi (Litchi chinensis) fruit products possess rich amounts of flavanoids and proanthocyanidins.
Its pericarp has been shown to inhibit breast and liver cancer cell growth.
However, the anticolorectal cancer effect of Litchi seed extract has not yet been reported.
In this study, the effects of polyphenol-rich Litchi seed ethanol extract (LCSP) on the proliferation, cell cycle, and apoptosis of two colorectal cancer cell lines Colo320DM and SW480 were examined.
The results demonstrated that LCSP significantly induced apoptotic cell death in a dose-dependent manner and arrested cell cycle in G2/M in colorectal carcinoma cells.
LCSP also suppressed cyclins and elevated the Bax : Bcl-2 ratio and caspase 3 activity.
This study provides in vitro evidence that LCSP serves as a potential chemopreventive agent for colorectal cancer.
American Psychological Association (APA)
Hsu, Chih-Ping& Lin, Chih-Cheng& Huang, Chiu-Chen& Lin, Yi-Hsien& Chou, Jyh-Ching& Tsia, Yu-Ting…[et al.]. 2012. Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464231
Modern Language Association (MLA)
Hsu, Chih-Ping…[et al.]. Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-464231
American Medical Association (AMA)
Hsu, Chih-Ping& Lin, Chih-Cheng& Huang, Chiu-Chen& Lin, Yi-Hsien& Chou, Jyh-Ching& Tsia, Yu-Ting…[et al.]. Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464231