C-Reactive Protein Levels in the Brugada Syndrome
Joint Authors
Gueffaf, Fatima
Himbert, Caroline
De Sisti, Antonio
Temfemo, Abdou
Bonny, Aimé
Ditah, Ivo
Tonet, Joelci
Frank, Robert
Fontaine, Guy
Hidden-Lucet, Françoise
Larrazet, Fabrice
Márquez, Manlio F.
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Inflammation in the Brugada syndrome (BrS) and its clinical implication have been little studied.
Aims.
To assess the level of inflammation in BrS patients.
Methods.
All studied BrS patients underwent blood samples drawn for C-reactive protein (CRP) levels at admission, prior to any invasive intervention.
Patients with a previous ICD placement were controlled to exclude those with a recent (<14 days) shock.
We divided subjects into symptomatic (syncope or aborted sudden death) and asymptomatic groups.
In a multivariable analysis, we adjusted for significant variables (age, CRP ≥ 2 mg/L).
Results.
Fifty-four subjects were studied (mean age 45 ± 13 years, 49 (91%) male).
Twenty (37%) were symptomatic.
Baseline characteristics were similar in both groups.
Mean CRP level was 1,4 ± 0,9 mg/L in asymptomatic and 2,4 ± 1,4 mg/L in symptomatic groups (P = .003).
In the multivariate model, CRP concentrations ≥ 2 mg/L remained an independent marker for being symptomatic (P = .018; 95% CI: 1.3 to 19.3).
Conclusion.
Inflammation seems to be more active in symptomatic BrS.
C-reactive protein concentrations ≥ 2 mg/L might be associated with the previous symptoms in BrS.
The value of inflammation as a risk factor of arrhythmic events in BrS needs to be studied.
American Psychological Association (APA)
Bonny, Aimé& Tonet, Joelci& Márquez, Manlio F.& De Sisti, Antonio& Temfemo, Abdou& Himbert, Caroline…[et al.]. 2011. C-Reactive Protein Levels in the Brugada Syndrome. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-464238
Modern Language Association (MLA)
Bonny, Aimé…[et al.]. C-Reactive Protein Levels in the Brugada Syndrome. Cardiology Research and Practice No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-464238
American Medical Association (AMA)
Bonny, Aimé& Tonet, Joelci& Márquez, Manlio F.& De Sisti, Antonio& Temfemo, Abdou& Himbert, Caroline…[et al.]. C-Reactive Protein Levels in the Brugada Syndrome. Cardiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-464238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464238