Targeting the HGF-cMET Axis in Hepatocellular Carcinoma
Joint Authors
Goff, Laura
Venepalli, Neeta K.
Source
International Journal of Hepatology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Under normal physiological conditions, the hepatocyte growth factor (HGF) and its receptor, the MET transmembrane tyrosine kinase (cMET), are involved in embryogenesis, morphogenesis, and wound healing.
The HGF-cMET axis promotes cell survival, proliferation, migration, and invasion via modulation of epithelial-mesenchymal interactions.
Hepatocellular cancer (HCC) is the third most common cause of worldwide cancer-related mortality; advanced disease is associated with a paucity of therapeutic options and a five-year survival rate of only 10%.
Dysregulation of the HGF-cMET pathway is implicated in HCC carcinogenesis and progression through activation of multiple signaling pathways; therefore, cMET inhibition is a promising therapeutic strategy for HCC treatment.
The authors review HGF-cMET structure and function in normal tissue and in HCC, cMET inhibition in HCC, and future strategies for biomarker identification.
American Psychological Association (APA)
Venepalli, Neeta K.& Goff, Laura. 2013. Targeting the HGF-cMET Axis in Hepatocellular Carcinoma. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-464251
Modern Language Association (MLA)
Venepalli, Neeta K.& Goff, Laura. Targeting the HGF-cMET Axis in Hepatocellular Carcinoma. International Journal of Hepatology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-464251
American Medical Association (AMA)
Venepalli, Neeta K.& Goff, Laura. Targeting the HGF-cMET Axis in Hepatocellular Carcinoma. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-464251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464251