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PPAR-γ Signaling Crosstalk in Mesenchymal Stem Cells
Joint Authors
Takada, Ichiro
Kouzmenko, Alexander P.
Kato, Shigeaki
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor-gamma (PPAR-γ) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcriptional factors.
Among other functions, PPAR-γ acts as a key regulator of the adipogenesis.
Since several cytokines (IL-1, TNF-α, TGF-β) had been known to inhibit adipocyte differentiation in mesenchymal stem cells (MSCs), we examined the effect of these cytokines on the transactivation function of PPAR-γ.
We found that the TNF-α/IL-1-activated TAK1/TAB1/NIK (NFκB-inducible kinase) signaling cascade inhibited both the adipogenesis and Tro-induced transactivation by PPAR-γ by blocking the receptor binding to the cognate DNA response elements.
Furthermore, it has been shown that the noncanonical Wnts are expressed in MSCs and that Wnt-5a was capable to inhibit transactivation by PPAR-γ.
Treatment with Wnt5a-activated NLK (nemo-like kinase) induced physical association of the endogenous NLK and H3K9 histone methyltransferase (SETDB1) protein complexes with PPAR-γ.
This resulted in histoneH3K9 tri-methylation at PPAR-γ target gene promoters.
Overall, our data show that cytokines and noncanonical Wnts play a crucial role in modulation of PPAR-γ regulatory function in its target cells and tissues.
American Psychological Association (APA)
Takada, Ichiro& Kouzmenko, Alexander P.& Kato, Shigeaki. 2010. PPAR-γ Signaling Crosstalk in Mesenchymal Stem Cells. PPAR Research،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-464258
Modern Language Association (MLA)
Takada, Ichiro…[et al.]. PPAR-γ Signaling Crosstalk in Mesenchymal Stem Cells. PPAR Research No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-464258
American Medical Association (AMA)
Takada, Ichiro& Kouzmenko, Alexander P.& Kato, Shigeaki. PPAR-γ Signaling Crosstalk in Mesenchymal Stem Cells. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-464258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464258