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Hemolytic Uremic Syndrome : Late Renal Injury and Changing Incidence—A Single Centre Experience in Canada
Joint Authors
Clermont, Marie-José
Mérouani, Aïcha
Phan, Véronique
Lapeyraque, Anne-Laure
Robitaille, Pierre
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Aims.
To assess trends in the incidence of pediatric diarrhea-associated hemolytic uremic syndrome (D+ HUS) and document long-term renal sequelae.
Methods.
We conducted a retrospective cohort study of children with D+ HUS admitted to a tertiary care pediatric hospital in Montreal, Canada, from 1976 to 2010.
In 2010, we recontacted patients admitted before 2000.
Results.
Of 337 cases, median age at presentation was 3.01 years (range 0.4–14).
Yearly incidence peaked in 1988 and 1994-95, returning to near-1977 levels since 2003.
Twelve patients (3.6%) died and 19 (5.6%) experienced long-term renal failure.
Almost half (47%) The patients required dialysis.
Need for dialysis was the best predictor of renal sequelae, accounting for 100% of severe complications.
Of children followed ≥1 year (n=199, mean follow-up 8.20±6.78 years), 19 had severe and 18 mild-to-moderate kidney injury, a total sequelae rate, of 18.6%.
Ten years or more after-HUS (n=85, mean follow-up 15.4±5.32 years), 8 (9.4%) patients demonstrated serious complications and 22 (25.9%) mild-to-moderate, including 14 (16%) microalbuminuria: total sequelae, 35.3%.
Conclusions.
Patients with D+ HUS should be monitored at least 5 years, including microalbuminuria testing, especially if dialysis was required.
The cause of the declining incidence of D+HUS is elusive.
However, conceivably, improved public health education may have played an important role in the prevention of food-borne disease.
American Psychological Association (APA)
Robitaille, Pierre& Clermont, Marie-José& Mérouani, Aïcha& Phan, Véronique& Lapeyraque, Anne-Laure. 2012. Hemolytic Uremic Syndrome : Late Renal Injury and Changing Incidence—A Single Centre Experience in Canada. Scientifica،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464277
Modern Language Association (MLA)
Robitaille, Pierre…[et al.]. Hemolytic Uremic Syndrome : Late Renal Injury and Changing Incidence—A Single Centre Experience in Canada. Scientifica No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-464277
American Medical Association (AMA)
Robitaille, Pierre& Clermont, Marie-José& Mérouani, Aïcha& Phan, Véronique& Lapeyraque, Anne-Laure. Hemolytic Uremic Syndrome : Late Renal Injury and Changing Incidence—A Single Centre Experience in Canada. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464277