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In with the Old, in with the New : The Promiscuity of the Duplication Process Engenders Diverse Pathways for Novel Gene Creation
Author
Source
International Journal of Evolutionary Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
The gene duplication process has exhibited far greater promiscuity in the creation of paralogs with novel exon-intron structures than anticipated even by Ohno.
In this paper I explore the history of the field, from the neo-Darwinian synthesis through Ohno’s formulation of the canonical model for the evolution of gene duplicates and culminating in the present genomic era.
I delineate the major tenets of Ohno’s model and discuss its failure to encapsulate the full complexity of the duplication process as revealed in the era of genomics.
I discuss the diverse classes of paralogs originating from both DNA- and RNA-mediated duplication events and their evolutionary potential for assuming radically altered functions, as well as the degree to which they can function unconstrained from the pressure of gene conversion.
Lastly, I explore theoretical population-genetic considerations of how the effective population size (Ne) of a species may influence the probability of emergence of genes with radically altered functions.
American Psychological Association (APA)
Katju, Vaishali. 2012. In with the Old, in with the New : The Promiscuity of the Duplication Process Engenders Diverse Pathways for Novel Gene Creation. International Journal of Evolutionary Biology،Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-464283
Modern Language Association (MLA)
Katju, Vaishali. In with the Old, in with the New : The Promiscuity of the Duplication Process Engenders Diverse Pathways for Novel Gene Creation. International Journal of Evolutionary Biology No. 2012 (2012), pp.1-24.
https://search.emarefa.net/detail/BIM-464283
American Medical Association (AMA)
Katju, Vaishali. In with the Old, in with the New : The Promiscuity of the Duplication Process Engenders Diverse Pathways for Novel Gene Creation. International Journal of Evolutionary Biology. 2012. Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-464283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464283