Results of Gamma Knife Radiosurgery in Acromegaly
Joint Authors
Spatola, Giorgio
Mortini, Pietro
Picozzi, Piero
Franzin, Alberto
Losa, Marco
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Single-session radiosurgery with Gamma Knife (GK) may be a potential adjuvant treatment in acromegaly.
We analyzed the safety and efficacy of GK in patients who had previously received maximal surgical debulking at our hospital.
Methods.
The study was a retrospective analysis of hormonal, radiological, and ophthalmologic data collected in a predefined protocol from 1994 to 2009.
The mean age at treatment was 42.3 years (range 22–67 yy).
103 acromegalic patients participated in the study.
The median follow-up was 71 months (IQ range 43–107).
All patients were treated with GK for residual or recurrent GH-secreting adenoma.
Results.
Sixty-three patients (61.2%) reached the main outcome of the study.
The rate of remission was 58.3% at 5 years (95% CI 47.6–69.0%).
Other 15 patients (14.6%) were in remission after GK while on treatment with somatostatin analogues.
No serious side effects occurred after GK.
Eight patients (7.8%) experienced a new deficit of pituitary function.
New cases of hypogonadism, hypothyroidism, and hypoadrenalism occurred in 4 of 77 patients (5.2%), 3 of 95 patients (3.2%), and 6 of 100 patients at risk (6.0%), respectively.
Conclusion.
In a highly selected group of acromegalic patients, GK treatment had good efficacy and safety.
American Psychological Association (APA)
Franzin, Alberto& Spatola, Giorgio& Losa, Marco& Picozzi, Piero& Mortini, Pietro. 2012. Results of Gamma Knife Radiosurgery in Acromegaly. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-464291
Modern Language Association (MLA)
Franzin, Alberto…[et al.]. Results of Gamma Knife Radiosurgery in Acromegaly. International Journal of Endocrinology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-464291
American Medical Association (AMA)
Franzin, Alberto& Spatola, Giorgio& Losa, Marco& Picozzi, Piero& Mortini, Pietro. Results of Gamma Knife Radiosurgery in Acromegaly. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-464291
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464291