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Evaluation of Cytokines in Endocervical Secretion and Vaginal pH from Women with Bacterial Vaginosis or Human Papillomavirus
Joint Authors
Campos, Ana Claudia Camargo
Reis, Cleomenes
Michelin, Márcia Antoniazi
Murta, Eddie Fernando Candido
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To verify the relationship between vaginal pH and human papillomavirus (HPV) infection and to measure cytokine levels in endocervical secretions of women with bacterial vaginosis (BV) or HPV.
Methods.
173 women (16–48 years old) were enrolled and divided into groups: BV, HPV, and controls.
Microbiological culture and vaginal pH were measured.
HPV detect by PCR, and cytokines by ELISA (IL-2, IL-6, IL-10, IL-12, TNF-α, and IFN-γ cytokines).
Results.
Of 173 women, 60 were control group (34.7%) and 113 were distributed in HPV (n=36, 20.8%), BV (n=36, 20.8%), vaginitis (n=30, 17.3%) and, BV and HPV-associated groups (n=11, 6.4%).
Vaginal pH > 4.5 was related with HPV infection.
IL-2 and IL-12 were increased in BV and HPV groups, and IL-6 (only BV group), compared to control group.
IL-12 and IFN-γ were higher in HPV than BV group.
Conclusion.
The increase of vaginal pH was associated with HPV infection; BV and HPV groups had a Th1 cytokines immune response.
American Psychological Association (APA)
Campos, Ana Claudia Camargo& Murta, Eddie Fernando Candido& Michelin, Márcia Antoniazi& Reis, Cleomenes. 2012. Evaluation of Cytokines in Endocervical Secretion and Vaginal pH from Women with Bacterial Vaginosis or Human Papillomavirus. ISRN Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464296
Modern Language Association (MLA)
Campos, Ana Claudia Camargo…[et al.]. Evaluation of Cytokines in Endocervical Secretion and Vaginal pH from Women with Bacterial Vaginosis or Human Papillomavirus. ISRN Obstetrics and Gynecology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-464296
American Medical Association (AMA)
Campos, Ana Claudia Camargo& Murta, Eddie Fernando Candido& Michelin, Márcia Antoniazi& Reis, Cleomenes. Evaluation of Cytokines in Endocervical Secretion and Vaginal pH from Women with Bacterial Vaginosis or Human Papillomavirus. ISRN Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464296