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Efficiency and Safety of Prolonged Levosimendan Infusion in Patients with Acute Heart Failure
Joint Authors
Kanonidis, Ioannis
Aidonidis, Georgios
Sakadamis, Georgios
Koutsimanis, Vasileios
Erbel, Raimund
Neumann, Till
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Levosimendan is an inotropic drug with unique pharmacological advantages in patients with acute heart failure.
Scope of this study is to determine whether longer infusion patterns without the hypotension-inducing loading dose could justify an effective and safe alternative approach.
Methods.
70 patients admitted to the emergencies with decompensated chronic heart failure received intravenously levosimendan without a loading dose up to 72 hours.
Clinical parameters, BNP (Brain Natriuretic Peptide) and signal-averaged-ECG data (SAECG) were recorded up to 72 hours.
Results.
The 48-hour group demonstrated a statistically significant BNP decrease (P<.001) after 48 hours, which also maintained after 72 hours.
The 72-hour group demonstrated a bordeline decrease of BNP after 48 hours (P=.039), necessitating an additional 24-hour infusion to achieve significant reduction after 72 hours (P<.004).
SAECG data demonstrated a statistically significant decrease after 72 hours (P<.04).
Apart from two deaths due to advanced heart failure, no major complications were observed.
Conclusion.
Prolonged infusion of levosimendan without a loading dose is associated with an acceptable clinical and neurohumoral response.
American Psychological Association (APA)
Aidonidis, Georgios& Kanonidis, Ioannis& Koutsimanis, Vasileios& Neumann, Till& Erbel, Raimund& Sakadamis, Georgios. 2011. Efficiency and Safety of Prolonged Levosimendan Infusion in Patients with Acute Heart Failure. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-464307
Modern Language Association (MLA)
Aidonidis, Georgios…[et al.]. Efficiency and Safety of Prolonged Levosimendan Infusion in Patients with Acute Heart Failure. Cardiology Research and Practice No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-464307
American Medical Association (AMA)
Aidonidis, Georgios& Kanonidis, Ioannis& Koutsimanis, Vasileios& Neumann, Till& Erbel, Raimund& Sakadamis, Georgios. Efficiency and Safety of Prolonged Levosimendan Infusion in Patients with Acute Heart Failure. Cardiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-464307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464307