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Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus
Joint Authors
Vanhems, P.
El Garch, H.
Grenier, E.
Brunet, S.
Poulet, H.
Castiglione, Filippo
Ribba, B.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Studies of the response of the immune system to feline immunodeficiency virus (FIV) during primary infection have shown that a subpopulation of CD8+ T-cells with an activated phenotype and reduced expression of the CD8β chain (denoted CD8βlow T cells) expands to reach up to 80% of the total CD8+ T cell count.
The expansion of this subpopulation is considered to be a signature of FIV and an indicator of immune system alteration.
We use a simple mathematical formalism to study the relationships over time between the dose of infection, the size of the CD8βlow population, and the circulating viral load in cats infected with FIV.
Viremia profiles are described using a combination of two exponential laws, whereas the CD8βlow percentage (out of the total CD8+ population) is represented by a Gompertz law including an expansion phase and a saturation phase.
Model parameters are estimated with a population approach using data from 102 experimentally infected cats.
We examine the dose of infection as a potential covariate of parameters.
We find that the rates of increase of viral load and of CD8βlow percentage are both correlated with the dose of infection.
Cats that develop strong acute viremia also show the largest degree of CD8βlow expansion.
The two simple models are robust tools for analysing the time course of CD8βlow percentage and circulating viral load in FIV-infected cats and may be useful for generating new insights on the disease and on the design of therapeutic strategies, potentially applicable to HIV infection.
American Psychological Association (APA)
Ribba, B.& El Garch, H.& Brunet, S.& Grenier, E.& Castiglione, Filippo& Poulet, H.…[et al.]. 2012. Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-464333
Modern Language Association (MLA)
Ribba, B.…[et al.]. Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-464333
American Medical Association (AMA)
Ribba, B.& El Garch, H.& Brunet, S.& Grenier, E.& Castiglione, Filippo& Poulet, H.…[et al.]. Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-464333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464333