Immunomorphologic Manifestations in Mice Liver Infected with Influenza AH5N1, AGooseKrasnoozerskoye62705 Strain
Joint Authors
Sharkova, Tatyana V.
Potapova, Oxana V.
Shestopalov, Alexander M.
Shkurupiy, Vyacheslav A.
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Highly pathogenic avian influenza H5N1 (HPAI H5N1) viruses can infect mammals, including humans, causing severe systemic disease with the inhibition of the immune system and a high mortality rate.
In conditions of lymphoid tissue depletion, the liver plays an important role in host defence against viruses.
The changes in mice liver infected with HPAI H5N1 virus A/goose/Krasnoozerskoye/627/05 have been studied.
It has been shown that the virus persistence in the liver leads to the expression of proinflammatory cytokines (TNF-α, IL-6) and intracellular proteases (lysozyme, cathepsin D, and myeloperoxidase) by Kupffer cells.
Defective antiviral response exacerbates destructive processes in the liver accelerating the development of liver failure.
American Psychological Association (APA)
Potapova, Oxana V.& Sharkova, Tatyana V.& Shkurupiy, Vyacheslav A.& Shestopalov, Alexander M.. 2013. Immunomorphologic Manifestations in Mice Liver Infected with Influenza AH5N1, AGooseKrasnoozerskoye62705 Strain. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-464344
Modern Language Association (MLA)
Potapova, Oxana V.…[et al.]. Immunomorphologic Manifestations in Mice Liver Infected with Influenza AH5N1, AGooseKrasnoozerskoye62705 Strain. Clinical and Developmental Immunology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-464344
American Medical Association (AMA)
Potapova, Oxana V.& Sharkova, Tatyana V.& Shkurupiy, Vyacheslav A.& Shestopalov, Alexander M.. Immunomorphologic Manifestations in Mice Liver Infected with Influenza AH5N1, AGooseKrasnoozerskoye62705 Strain. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-464344
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464344
