Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration
Joint Authors
Trabelsi, Sameh
Lakhal, Mohamed
Salouage, Issam
Gaies, Emna
Kouz, Anis
Ben Fradj, Nadia
ELjebari, Hanene
Ben Othman, Tarek
Jebabli, Nadia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Measurements of Cyclosporine (CsA) systemic exposure permit its dose adjustment in allogenic stem cell transplantation recipients to prevent graft-versus-host disease.
CsA LSSs were developed and validated from 60 ASCT patients via multiple linear regressions.
All whole-blood samples were analyzed by fluorescence polarization immunoassay (FPIA-Axym).
The 10 models that have used CsA concentrations at a single time point did not have a good fit with AUC0–12 (R2<0.90).
C2 and C4 were the time points that correlated best with AUC0–12 h, R2 were respectively 0.848, and 0.897.
The LSS equation with the best predictive performance (bias, precision and number of samples) utilized three sampling concentrations was AUC0–12 h= 0.607+1.569× C0.5+2.098× C2+ 3.603× C4 (R2 = 0.943).
Optimal LSSs equations which limited to those utilizing three timed concentrations taken within 4 hours post-dose developed from ASCT recipient's patients yielded a low bias <5% ranged from 1.27% to 2.68% and good precision <15% ranged from 9.60% and 11.02%.
We propose an LSS model with equation AUC0–12 h=0.82+2.766× C2+3.409×C4 for a practical reason.
Bias and precision for this model are respectively 2.68% and 11.02%.
American Psychological Association (APA)
ELjebari, Hanene& Ben Fradj, Nadia& Salouage, Issam& Gaies, Emna& Trabelsi, Sameh& Jebabli, Nadia…[et al.]. 2011. Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464346
Modern Language Association (MLA)
ELjebari, Hanene…[et al.]. Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration. Journal of Transplantation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-464346
American Medical Association (AMA)
ELjebari, Hanene& Ben Fradj, Nadia& Salouage, Issam& Gaies, Emna& Trabelsi, Sameh& Jebabli, Nadia…[et al.]. Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration. Journal of Transplantation. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464346