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Antinociceptive Activity of the Chloroform Fraction of Dioclea virgata (Rich.) Amshoff (Fabaceae) in Mice
Joint Authors
de Morais, Liana Clébia Soares Lima
Bhattacharyya, Jnanabrata
Almeida, Reinaldo Nóbrega de
de Carvalho, Fabíola Lélis
Mota, Vanine Gomes
de Alencar, Jacicarlos Lima
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Acute treatment with the chloroform fraction of Dioclea virgata (Rich.) Amshoff (CFDv) in mice produced decreased ambulation and sedation in the behavioral pharmacological screening.
Doses of 125 and 250 mg/kg CFDv decreased latency of sleep onset in the test of sleeping time potentiation.
In the open field, animals treated with CFDv reduced ambulation and rearing (250 mg/kg), as well as defecation (125; 250 mg/kg).
Regarding the antinociceptive activity, CFDv (125, 250, 500 mg/kg) increased latency to first writhing and decreased the number of writhings induced by acetic acid.
In the formalin test, CFDv (250 mg/kg) decreased paw licking time in the first and second phases indicating antinociceptive activity that can be mediated both peripherally and at the central level.
CFDv did not affect motor coordination until 120 minutes after treatment.
CFDv shows psychopharmacological effects suggestive of CNS-depressant drugs with promising antinociceptive activity.
American Psychological Association (APA)
Mota, Vanine Gomes& de Carvalho, Fabíola Lélis& de Morais, Liana Clébia Soares Lima& Bhattacharyya, Jnanabrata& Almeida, Reinaldo Nóbrega de& de Alencar, Jacicarlos Lima. 2011. Antinociceptive Activity of the Chloroform Fraction of Dioclea virgata (Rich.) Amshoff (Fabaceae) in Mice. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-464355
Modern Language Association (MLA)
Mota, Vanine Gomes…[et al.]. Antinociceptive Activity of the Chloroform Fraction of Dioclea virgata (Rich.) Amshoff (Fabaceae) in Mice. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-464355
American Medical Association (AMA)
Mota, Vanine Gomes& de Carvalho, Fabíola Lélis& de Morais, Liana Clébia Soares Lima& Bhattacharyya, Jnanabrata& Almeida, Reinaldo Nóbrega de& de Alencar, Jacicarlos Lima. Antinociceptive Activity of the Chloroform Fraction of Dioclea virgata (Rich.) Amshoff (Fabaceae) in Mice. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-464355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464355