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Atypical Febrile Seizures, Mesial Temporal Lobe Epilepsy, and Dual Pathology
Joint Authors
Carmant, Lionel
Sanon, Nathalie T.
Desgent, Sébastien
Source
Epilepsy Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Febrile seizures occurring in the neonatal period, especially when prolonged, are thought to be involved in the later development of mesial temporal lobe epilepsy (mTLE) in children.
The presence of an often undetected, underlying cortical malformation has also been reported to be implicated in the epileptogenesis process following febrile seizures.
This paper highlights some of the various animal models of febrile seizures and of cortical malformation and portrays a two-hit model that efficiently mimics these two insults and leads to spontaneous recurrent seizures in adult rats.
Potential mechanisms are further proposed to explain how these two insults may each, or together, contribute to network hyperexcitability and epileptogenesis.
Finally the clinical relevance of the two-hit model is briefly discussed in light of a therapeutic and preventive approach to mTLE.
American Psychological Association (APA)
Sanon, Nathalie T.& Desgent, Sébastien& Carmant, Lionel. 2012. Atypical Febrile Seizures, Mesial Temporal Lobe Epilepsy, and Dual Pathology. Epilepsy Research and Treatment،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-464371
Modern Language Association (MLA)
Sanon, Nathalie T.…[et al.]. Atypical Febrile Seizures, Mesial Temporal Lobe Epilepsy, and Dual Pathology. Epilepsy Research and Treatment No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-464371
American Medical Association (AMA)
Sanon, Nathalie T.& Desgent, Sébastien& Carmant, Lionel. Atypical Febrile Seizures, Mesial Temporal Lobe Epilepsy, and Dual Pathology. Epilepsy Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-464371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464371