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Successful Pregnancy in a Patient with Combined Deficiency of Factor V and Factor VIII
Joint Authors
Soumani, Abderraouf
Harou, Karam
Majdi, Farah
Younous, Said
El Adib, Ahmed Ghassan
Bassir, Ahlam
Asmouki, Hamid
Mahmal, Lahoucine
Dilai, Mohamed Othmane
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Inherited combined factor V and factor VIII deficiency (F5F8D) is autosomal recessive transmission disorder.
Epistaxis, postsurgical bleeding, and menorrhagia are the most common symptoms.
The risk of miscarriage and placental abruption is consequent.
We report a case of successful pregnancy in a patient with F5F8D.
20-year-old woman, born of consanguineous parents, third gestate, first parity, two miscarriages, admitted for child birth of a spontaneous pregnancy estimated at 38 weeks and was diagnosed with F5F8D.
At admission, patient was hemodynamically stable, with good obstetric conditions.
The biologic results showed low levels of PT (52%), factor V (7%), and factor VIII (5%), and the activated partial thromboplastin time was prolonged (68,6%).
Parturient was admitted in intensive care unit, maternal and fetal monitoring was performed.
Fresh frozen plasma (FFP) and factor VIII concentrates were perfused at the induction of labor.
Analgesia used fentanyl titration.
The delivery gave birth to a newborn male, with Apgar 10/10 and 3000 g.
The puerperium was simple without any important bleeding.
Laboratory tests for the newborn were acceptable.
Little literature is available on this subject and there are no guidelines available concerning pregnancy; we chose to prescribe a combination of factor VIII concentrate and FFP in pre-, per- and postpartum.
The same protocol was successfully used in a patient before dental extraction and prostatectomy.
Vaginal delivery is possible, as our case.
Management by multidisciplinary team is recommended.
American Psychological Association (APA)
El Adib, Ahmed Ghassan& Majdi, Farah& Dilai, Mohamed Othmane& Asmouki, Hamid& Bassir, Ahlam& Harou, Karam…[et al.]. 2014. Successful Pregnancy in a Patient with Combined Deficiency of Factor V and Factor VIII. Case Reports in Obstetrics and Gynecology،Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-464418
Modern Language Association (MLA)
El Adib, Ahmed Ghassan…[et al.]. Successful Pregnancy in a Patient with Combined Deficiency of Factor V and Factor VIII. Case Reports in Obstetrics and Gynecology No. 2014 (2014), pp.1-3.
https://search.emarefa.net/detail/BIM-464418
American Medical Association (AMA)
El Adib, Ahmed Ghassan& Majdi, Farah& Dilai, Mohamed Othmane& Asmouki, Hamid& Bassir, Ahlam& Harou, Karam…[et al.]. Successful Pregnancy in a Patient with Combined Deficiency of Factor V and Factor VIII. Case Reports in Obstetrics and Gynecology. 2014. Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-464418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464418