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Evasion of Host Defence by Leishmania donovani : Subversion of Signaling Pathways
Joint Authors
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Protozoan parasites of the genus Leishmania are responsible for causing a variety of human diseases known as leishmaniasis, which range from self-healing skin lesions to severe infection of visceral organs that are often fatal if left untreated.
Leishmania donovani (L.
donovani), the causative agent of visceral leishmaniasis, exemplifys a devious organism that has developed the ability to invade and replicate within host macrophage.
In fact, the parasite has evolved strategies to interfere with a broad range of signaling processes in macrophage that includes Protein Kinase C, the JAK2/STAT1 cascade, and the MAP Kinase pathway.
This paper focuses on how L.
donovani modulates these signaling pathways that favour its survival and persistence in host cells.
American Psychological Association (APA)
Shadab, Md.& Ali, Nahid. 2011. Evasion of Host Defence by Leishmania donovani : Subversion of Signaling Pathways. Molecular Biology International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-464436
Modern Language Association (MLA)
Shadab, Md.& Ali, Nahid. Evasion of Host Defence by Leishmania donovani : Subversion of Signaling Pathways. Molecular Biology International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-464436
American Medical Association (AMA)
Shadab, Md.& Ali, Nahid. Evasion of Host Defence by Leishmania donovani : Subversion of Signaling Pathways. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-464436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464436