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Clostridium difficile Infection and Proton Pump Inhibitor Use in Hospitalized Pediatric Cystic Fibrosis Patients
Joint Authors
Crowell, Kody
Patel, Raza A.
Zobell, Jeffery T.
Korgenski, E. Kent
Larsen, Christian
Lin, Ellen
Chatfield, Barbara A.
Pohl, John F.
MacKay, Mark W.
Richman, Aleesha
Source
Gastroenterology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Children with cystic fibrosis (CF) often take proton pump inhibitors (PPIs), which helps improve efficacy of fat absorption with pancreatic enzyme replacement therapy.
However, PPI use is known to be associated with Clostridium difficile-(C.
diff-) associated diarrhea (CDAD).
We retrospectively evaluated the incidence of C.
diff infection from all pediatric hospital admissions over a 5-year period at a single tertiary children's hospital.
We found significantly more C.
diff-positive stool tests in hospitalized patients with CF compared to patients with no diagnosis of CF.
However, use of a PPI was not associated with an increased risk of CDAD in hospitalized CF patients.
In summary, C.
diff infection is more common in hospitalized pediatric CF patients although PPI use may not be a risk factor for CDAD development in this patient population.
American Psychological Association (APA)
Pohl, John F.& Patel, Raza A.& Zobell, Jeffery T.& Lin, Ellen& Korgenski, E. Kent& Crowell, Kody…[et al.]. 2011. Clostridium difficile Infection and Proton Pump Inhibitor Use in Hospitalized Pediatric Cystic Fibrosis Patients. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-464439
Modern Language Association (MLA)
Pohl, John F.…[et al.]. Clostridium difficile Infection and Proton Pump Inhibitor Use in Hospitalized Pediatric Cystic Fibrosis Patients. Gastroenterology Research and Practice No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-464439
American Medical Association (AMA)
Pohl, John F.& Patel, Raza A.& Zobell, Jeffery T.& Lin, Ellen& Korgenski, E. Kent& Crowell, Kody…[et al.]. Clostridium difficile Infection and Proton Pump Inhibitor Use in Hospitalized Pediatric Cystic Fibrosis Patients. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-464439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464439