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Evaluation of Antithrombogenicity and Hydrophilicity on Zein-SWCNT Electrospun Fibrous Nanocomposite Scaffolds
Joint Authors
Kumar, D. Sakthi
Varghese, Saino Hanna
Dhandayuthapani, Brahatheeswaran
Maekawa, Toru
Aswathy, Ravindran Girija
Yoshida, Yasuhiko
Source
International Journal of Biomaterials
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Design of blood compatible surfaces is required to minimize platelet surface interactions and increase the thromboresistance of foreign surfaces when they are used as biomaterials especially for artificial blood prostheses.
In this study, single wall carbon nanotubes (SWCNTs) and Zein fibrous nanocomposite scaffolds were fabricated by electrospinning and evaluated its antithrombogenicity and hydrophilicity.
The uniform and highly smooth nanofibers of Zein composited with different SWCNTs content (ranging from 0.2 wt% to 1 wt%) were successfully prepared by electrospinning method without the occurrence of bead defects.
The resulting fiber diameters were in the range of 100–300 nm without any beads.
Composite nanofibers with and without SWCNT were characterized through a variety of methods including scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and tensile mechanical testing.
The water uptake and retention ability of composite scaffolds decreased whereas thermal stability increased with an addition of SWCNTs.
Hemolytic property and platelet adhesion ability of the nanocomposite (Zein-SWCNTs) were explored.
These observations suggest that the novel Zein-SWCNTs composite scaffolds may possibly hold great promises as useful antithrombotic material and promising biomaterials for tissue engineering application.
American Psychological Association (APA)
Dhandayuthapani, Brahatheeswaran& Varghese, Saino Hanna& Aswathy, Ravindran Girija& Yoshida, Yasuhiko& Maekawa, Toru& Kumar, D. Sakthi. 2012. Evaluation of Antithrombogenicity and Hydrophilicity on Zein-SWCNT Electrospun Fibrous Nanocomposite Scaffolds. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-464440
Modern Language Association (MLA)
Dhandayuthapani, Brahatheeswaran…[et al.]. Evaluation of Antithrombogenicity and Hydrophilicity on Zein-SWCNT Electrospun Fibrous Nanocomposite Scaffolds. International Journal of Biomaterials No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-464440
American Medical Association (AMA)
Dhandayuthapani, Brahatheeswaran& Varghese, Saino Hanna& Aswathy, Ravindran Girija& Yoshida, Yasuhiko& Maekawa, Toru& Kumar, D. Sakthi. Evaluation of Antithrombogenicity and Hydrophilicity on Zein-SWCNT Electrospun Fibrous Nanocomposite Scaffolds. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-464440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464440