Pathobiology of Anaplastic Large Cell Lymphoma
Joint Authors
Gazzola, Anna
Piccaluga, Pier Paolo
Sagramoso-Sacchetti, Carlo A.
Inghirami, Giorgio
Mannu, Claudia
Sabattini, Elena
Roncolato, Fernando
Piva, Roberto
Agostinelli, Claudio
Bacci, Francesco
Pileri, Stefano A.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The authors revise the concept of anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds.
The main histological findings are illustrated with special reference to the cytological spectrum that is indeed characteristic of the tumor.
The phenotype is reported in detail: the expression of the ALK protein as well as the chromosomal abnormalities is discussed with their potential pathogenetic implications.
The clinical features of ALCL are presented by underlining the difference in terms of response to therapy and survival between the ALK-positive and ALK-negative forms.
Finally, the biological rationale for potential innovative targeted therapies is presented.
American Psychological Association (APA)
Piccaluga, Pier Paolo& Gazzola, Anna& Mannu, Claudia& Agostinelli, Claudio& Bacci, Francesco& Sabattini, Elena…[et al.]. 2011. Pathobiology of Anaplastic Large Cell Lymphoma. Advances in Hematology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-464442
Modern Language Association (MLA)
Piccaluga, Pier Paolo…[et al.]. Pathobiology of Anaplastic Large Cell Lymphoma. Advances in Hematology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-464442
American Medical Association (AMA)
Piccaluga, Pier Paolo& Gazzola, Anna& Mannu, Claudia& Agostinelli, Claudio& Bacci, Francesco& Sabattini, Elena…[et al.]. Pathobiology of Anaplastic Large Cell Lymphoma. Advances in Hematology. 2011. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-464442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464442