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Simultaneous Changes of Spatial Memory and Spine Density after Intrahippocampal Administration of Fibrillar Aβ1–42 to the Rat Brain
Joint Authors
Borbély, Emőke
Fülöp, Lívia
Horváth, János
Furdan, Szabina
Bozsó, Zsolt
Penke, Botond
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several animal models of Alzheimer’s disease have been used in laboratory experiments.
Intrahippocampal injection of fibrillar amyloid-beta (fAβ) peptide represents one of the most frequently used models, mimicking Aβ deposits in the brain.
In our experiment synthetic fAβ1–42 peptide was administered to rat hippocampus.
The effect of the Aβ peptide on spatial memory and dendritic spine density was studied.
The fAβ1–42-treated rats showed decreased spatial learning ability measured in Morris water maze (MWM).
Simultaneously, fAβ1–42 caused a significant reduction of the dendritic spine density in the rat hippocampus CA1 region.
The decrease of learning ability and the loss of spine density were in good correlation.
Our results prove that both methods (MWM and dendritic spine density measurement) are suitable for studying Aβ-triggered neurodegeneration processes.
American Psychological Association (APA)
Borbély, Emőke& Horváth, János& Furdan, Szabina& Bozsó, Zsolt& Penke, Botond& Fülöp, Lívia. 2014. Simultaneous Changes of Spatial Memory and Spine Density after Intrahippocampal Administration of Fibrillar Aβ1–42 to the Rat Brain. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-464469
Modern Language Association (MLA)
Borbély, Emőke…[et al.]. Simultaneous Changes of Spatial Memory and Spine Density after Intrahippocampal Administration of Fibrillar Aβ1–42 to the Rat Brain. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-464469
American Medical Association (AMA)
Borbély, Emőke& Horváth, János& Furdan, Szabina& Bozsó, Zsolt& Penke, Botond& Fülöp, Lívia. Simultaneous Changes of Spatial Memory and Spine Density after Intrahippocampal Administration of Fibrillar Aβ1–42 to the Rat Brain. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-464469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464469