Disturbed Copper Bioavailability in Alzheimer's Disease
Joint Authors
Bayer, Thomas A.
Multhaup, Gerd
Kaden, Daniela
Danzeisen, Ruth
Bush, Ashley I.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Recent data from in vitro, animal, and human studies have shed new light on the positive roles of copper in many aspects of AD.
Copper promotes the non-amyloidogenic processing of APP and thereby lowers the Aβ production in cell culture systems, and it increases lifetime and decreases soluble amyloid production in APP transgenic mice.
In a clinical trial with Alzheimer patients, the decline of Aβ levels in CSF, which is a diagnostic marker, is diminished in the verum group (8 mg copper/day), indicating a beneficial effect of the copper treatment.
These observations are in line with the benefit of treatment with compounds aimed at normalizing metal levels in the brain, such as PBT2.
The data reviewed here demonstrate that there is an apparent disturbance in metal homeostasis in AD.
More research is urgently needed to understand how this disturbance can be addressed therapeutically.
American Psychological Association (APA)
Kaden, Daniela& Bush, Ashley I.& Danzeisen, Ruth& Bayer, Thomas A.& Multhaup, Gerd. 2011. Disturbed Copper Bioavailability in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-464485
Modern Language Association (MLA)
Kaden, Daniela…[et al.]. Disturbed Copper Bioavailability in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-464485
American Medical Association (AMA)
Kaden, Daniela& Bush, Ashley I.& Danzeisen, Ruth& Bayer, Thomas A.& Multhaup, Gerd. Disturbed Copper Bioavailability in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-464485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464485