Possible Implication of Fcγ Receptor-Mediated Trogocytosis in Susceptibility to Systemic Autoimmune Disease
Joint Authors
Iwasaki, Sari
Tomaru, Utano
Katsumata, Kazuaki
Masuda, Sakiko
Ishizu, Akihiro
Baba, Tomohisa
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Leukocytes can “gnaw away” the plasma membrane of other cells.
This phenomenon, called trogocytosis, occurs subsequent to cell-to-cell adhesion.
Currently, two mechanisms of trogocytosis, adhesion molecule-mediated trogocytosis and Fcγ receptor-(FcγR-) mediated trogocytosis, have been identified.
In our earlier study, we established an in vitro model of FcγR-mediated trogocytosis, namely, CD8 translocation model from T cells to neutrophils.
By using this model, we demonstrated that the molecules transferred to neutrophils via FcγR-mediated trogocytosis were taken into the cytoplasm immediately.
This result suggests that the chance of molecules transferred via FcγR-mediated trogocytosis to play a role on the cell surface could be time-limited.
Thus, we consider the physiological role of FcγR-mediated trogocytosis as a means to remove antibodies (Abs) that bind with self-molecules rather than to extract molecules from other cells.
This concept means that FcγR-mediated trogocytosis can be a defense mechanism to Ab-mediated autoimmune response.
Moreover, the activity of FcγR-mediated trogocytosis was revealed to be parallel to the endocytotic activity of neutrophils, which was critically related to the susceptibility to systemic autoimmune diseases.
The collective findings suggest that FcγR-mediated trogocytosis could physiologically play a role in removal of Abs bound to self-antigens and prevent autoimmune diseases.
American Psychological Association (APA)
Masuda, Sakiko& Iwasaki, Sari& Tomaru, Utano& Baba, Tomohisa& Katsumata, Kazuaki& Ishizu, Akihiro. 2013. Possible Implication of Fcγ Receptor-Mediated Trogocytosis in Susceptibility to Systemic Autoimmune Disease. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-464496
Modern Language Association (MLA)
Masuda, Sakiko…[et al.]. Possible Implication of Fcγ Receptor-Mediated Trogocytosis in Susceptibility to Systemic Autoimmune Disease. Clinical and Developmental Immunology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-464496
American Medical Association (AMA)
Masuda, Sakiko& Iwasaki, Sari& Tomaru, Utano& Baba, Tomohisa& Katsumata, Kazuaki& Ishizu, Akihiro. Possible Implication of Fcγ Receptor-Mediated Trogocytosis in Susceptibility to Systemic Autoimmune Disease. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-464496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464496