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Modulation of Neutrophil Apoptosis by Antimicrobial Peptides
Joint Authors
Suzuki, Kaori
Hirata, Michimasa
Nagaoka, Isao
Tamura, Hiroshi
Niyonsaba, François
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Peptide antibiotics possess the potent antimicrobial activities against invading microorganisms and contribute to the innate host defense.
Human antimicrobial peptides, α-defensins (human neutrophil peptides, HNPs), human β-defensins (hBDs), and cathelicidin (LL-37) not only exhibit potent bactericidal activities against Gram-negative and Gram-positive bacteria, but also function as immunomodulatory molecules by inducing cytokine and chemokine production, and inflammatory and immune cell activation.
Neutrophil is a critical effector cell in host defense against microbial infection, and its lifespan is regulated by various pathogen- and host-derived substances.
Here, we provided the evidence that HNP-1, hBD-3, and LL-37 cannot only destroy bacteria but also potently modulate (suppress) neutrophil apoptosis, accompanied with the phosphorylation of ERK-1/-2, the downregulation of tBid (an proapoptotic protein) and upregulation of Bcl-xL (an antiapoptotic protein), and the inhibition of mitochondrial membrane potential change and caspase 3 activity, possibly via the actions on the distinct receptors, the P2Y6 nucleotide receptor, the chemokine receptor CCR6, and the low-affinity formyl-peptide receptor FPRL1/the nucleotide receptor P2X7, respectively.
Suppression of neutrophil apoptosis results in the prolongation of their lifespan and may be advantageous for the host defense against bacterial invasion.
American Psychological Association (APA)
Nagaoka, Isao& Suzuki, Kaori& Niyonsaba, François& Tamura, Hiroshi& Hirata, Michimasa. 2012. Modulation of Neutrophil Apoptosis by Antimicrobial Peptides. ISRN Microbiology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-464500
Modern Language Association (MLA)
Nagaoka, Isao…[et al.]. Modulation of Neutrophil Apoptosis by Antimicrobial Peptides. ISRN Microbiology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-464500
American Medical Association (AMA)
Nagaoka, Isao& Suzuki, Kaori& Niyonsaba, François& Tamura, Hiroshi& Hirata, Michimasa. Modulation of Neutrophil Apoptosis by Antimicrobial Peptides. ISRN Microbiology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-464500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464500