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Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-Induced PGE2, IL-6, and IL-8 Production
Joint Authors
Moilanen, Teemu
Moilanen, Eeva
Vuolteenaho, Katriina
Koskinen, Anna
Kukkonen, Meiju
Päivärinta, Unto
Nieminen, Riina
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Obesity is an important risk factor for osteoarthritis (OA) in weight-bearing joints, but also in hand joints, pointing to an obesity-related metabolic factor that influences on the pathogenesis of OA.
Leptin is an adipokine regulating energy balance, and it has recently been related also to arthritis and inflammation as a proinflammatory factor.
In the present paper, the effects of leptin on human OA cartilage were studied.
Leptin alone or in combination with IL-1 enhanced the expression of iNOS and COX-2, and production of NO, PGE2, IL-6, and IL-8.
The results suggest that the effects of leptin are mediated through activation of transcription factor nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathway c-Jun NH2-terminal kinase (JNK).
Interestingly, inhibition of leptin-induced NO production with a selective iNOS inhibitor 1400 W inhibited also the production of IL-6, IL-8, and PGE2, and this was reversed by exogenously added NO-donor SNAP, suggesting that the effects of leptin on IL-6, IL-8, and PGE2 production are dependent on NO.
These findings support the idea of leptin as a factor enhancing the production of proinflammatory factors in OA cartilage and as an agent contributing to the obesity-associated increased risk for osteoarthritis.
American Psychological Association (APA)
Vuolteenaho, Katriina& Koskinen, Anna& Kukkonen, Meiju& Nieminen, Riina& Päivärinta, Unto& Moilanen, Teemu…[et al.]. 2009. Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-Induced PGE2, IL-6, and IL-8 Production. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-464506
Modern Language Association (MLA)
Vuolteenaho, Katriina…[et al.]. Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-Induced PGE2, IL-6, and IL-8 Production. Mediators of Inflammation No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-464506
American Medical Association (AMA)
Vuolteenaho, Katriina& Koskinen, Anna& Kukkonen, Meiju& Nieminen, Riina& Päivärinta, Unto& Moilanen, Teemu…[et al.]. Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-Induced PGE2, IL-6, and IL-8 Production. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-464506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464506