Near-Infrared Resonance Energy Transfer Glucose Biosensors in Hybrid Microcapsule Carriers
Joint Authors
McShane, Michael J.
Chinnayelka, Swetha
Zhu, Huiguang
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Fluorescence-based sensing systems offer potential for noninvasive monitoring with implantable devices, but require carrier technologies that provide suitable immobilization, accessibility, and biocompatibility.
Recent developments towards this goal include a competitive binding assay for glucose that has been encapsulated in semipermeable microcapsule carriers.
This paper describes an extension of this work to increase the applicability to in vivo monitoring, wherein two significant developments are described: (1) a near-infrared resonance energy transfer system for transducing glucose concentration, and (2) novel hybrid organic-inorganic crosslinked microcapsules as carriers.
The quenching-based assay is a competitive binding (CB) system based on apo-glucose oxidase (AG) as the receptor and dextran as the competitive ligand.
The encapsulated quencher-labeled dextran and near infrared donor-labeled glucose receptor showed a stable and reversible response with tunable sensitivity of 1–5%/mM over the physiological range, making these transducers attractive for continuous monitoring for biomedical applications.
American Psychological Association (APA)
Chinnayelka, Swetha& Zhu, Huiguang& McShane, Michael J.. 2008. Near-Infrared Resonance Energy Transfer Glucose Biosensors in Hybrid Microcapsule Carriers. Journal of Sensors،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-464519
Modern Language Association (MLA)
Chinnayelka, Swetha…[et al.]. Near-Infrared Resonance Energy Transfer Glucose Biosensors in Hybrid Microcapsule Carriers. Journal of Sensors No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-464519
American Medical Association (AMA)
Chinnayelka, Swetha& Zhu, Huiguang& McShane, Michael J.. Near-Infrared Resonance Energy Transfer Glucose Biosensors in Hybrid Microcapsule Carriers. Journal of Sensors. 2008. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-464519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464519