Developmental Origins of Chronic Renal Disease : An Integrative Hypothesis
Joint Authors
Ligi, I.
Grandvuillemin, I.
Simeoni, Umberto
Boubred, F.
Saint-Faust, M.
Buffat, C.
Source
International Journal of Nephrology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cardiovascular diseases are one of the leading causes of mortality.
Hypertension (HT) is one of the principal risk factors associated with death.
Chronic kidney disease (CKD), which is probably underestimated, increases the risk and the severity of adverse cardiovascular events.
It is now recognized that low birth weight is a risk factor for these diseases, and this relationship is amplified by a rapid catch-up growth or overfeeding during infancy or childhood.
The pathophysiological and molecular mechanisms involved in the “early programming” of CKD are multiple and partially understood.
It has been proposed that the developmental programming of arterial hypertension and chronic kidney disease is related to a reduced nephron endowment.
However, this mechanism is still discussed.
This review discusses the complex relationship between birth weight and nephron endowment and how early growth and nutrition influence long term HT and CKD.
We hypothesize that fetal environment reduces moderately the nephron number which appears insufficient by itself to induce long term diseases.
Reduced nephron number constitutes a “factor of vulnerability” when additional factors, in particular a rapid postnatal growth or overfeeding, promote the early onset of diseases through a complex combination of various pathophysiological pathways.
American Psychological Association (APA)
Boubred, F.& Saint-Faust, M.& Buffat, C.& Ligi, I.& Grandvuillemin, I.& Simeoni, Umberto. 2013. Developmental Origins of Chronic Renal Disease : An Integrative Hypothesis. International Journal of Nephrology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-464527
Modern Language Association (MLA)
Boubred, F.…[et al.]. Developmental Origins of Chronic Renal Disease : An Integrative Hypothesis. International Journal of Nephrology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-464527
American Medical Association (AMA)
Boubred, F.& Saint-Faust, M.& Buffat, C.& Ligi, I.& Grandvuillemin, I.& Simeoni, Umberto. Developmental Origins of Chronic Renal Disease : An Integrative Hypothesis. International Journal of Nephrology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-464527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464527