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Pharmacokinetics of Oral Taurine in Healthy Volunteers
Joint Authors
Ghandforoush-Sattari, Mohammadreza
Thompson, John P.
Krishna, Channarayapatna V.
Mashayekhi, Siminozar
Routledge, Philipp A.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Taurine, a sulfur-containing amino acid, is a normal constituent of the human diet.
Little is known of the pharmacokinetics of taurine in man after oral administration.
We studied the pharmacokinetics of 4 g taurine in eight healthy male volunteers (median age 27.5, range 22–45) following orally administration in the fasting state in the morning.
Blood samples were taken at regular intervals and plasma taurine concentration was measured by a modified HPLC method.
Data were subjected to noncompartmental analysis.
Maximum plasma taurine concentration (Cmax) was measured at 1.5±0.6 hr after administration as 86.1±19.0 mg/L (0.69±0.15 mmol).
Plasma elimination half-life (T1/2) and the ratio of clearance/bioavailability (Cl/F) were 1.0±0.3 hr and 21.1±7.8 L/hr, respectively.
Since taurine is occasionally used in therapeutics as a medicine, the pharmacokinetics and effects of oral taurine in healthy volunteers would be useful in the future studies of taurine in pharmacology and nutrition.
American Psychological Association (APA)
Ghandforoush-Sattari, Mohammadreza& Mashayekhi, Siminozar& Krishna, Channarayapatna V.& Thompson, John P.& Routledge, Philipp A.. 2010. Pharmacokinetics of Oral Taurine in Healthy Volunteers. Journal of Amino Acids،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-464544
Modern Language Association (MLA)
Ghandforoush-Sattari, Mohammadreza…[et al.]. Pharmacokinetics of Oral Taurine in Healthy Volunteers. Journal of Amino Acids No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-464544
American Medical Association (AMA)
Ghandforoush-Sattari, Mohammadreza& Mashayekhi, Siminozar& Krishna, Channarayapatna V.& Thompson, John P.& Routledge, Philipp A.. Pharmacokinetics of Oral Taurine in Healthy Volunteers. Journal of Amino Acids. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-464544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464544