Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis
Joint Authors
Sattler, Fred
Louie, Stan
Azen, Colleen G.
Jones, Brenda
Sanchez, Alejandro
Source
Tuberculosis Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Tuberculosis causes inflammation and muscle wasting.
We investigated how attenuation of inflammation relates to repletion of body composition during treatment in an underserved population.
Design.
Twenty-four patients (23 to 79 years old) with pulmonary tuberculosis and inflammation (pretreatment albumin =2.96±0.13 g/dL, C-reactive protein [CRP] =6.71±1.34 μg/dL, and beta-2-microglobulin =1.68±0.10 μg/L) were evaluated and had BIA over 24 weeks.
Results.
Weight increased by 3.02±0.81 kg (5.5%; P=0.007) at week 4 and by 8.59±0.97 kg (15.6%; P<0.0001) at week 24.
Repletion of body mass was primarily fat, which increased by 2.09±0.52 kg at week 4 and 5.05±0.56 kg at week 24 (P=0.004 and P<0.0001 versus baseline).
Fat-free mass (FFM), body cell mass (BCM), and phase angle did not increase until study week 8.
Albumin rose to 3.65±0.14 g/dL by week 4 (P<0.001) and slowly increased thereafter.
CRP levels declined by ∼50% at each interval visit.
Conclusions.
During the initial treatment, acute phase reactants returned towards normal.
The predominant accrual of fat mass probably reflects ongoing, low levels of inflammation.
American Psychological Association (APA)
Sanchez, Alejandro& Azen, Colleen G.& Jones, Brenda& Louie, Stan& Sattler, Fred. 2011. Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis. Tuberculosis Research and Treatment،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-464552
Modern Language Association (MLA)
Sanchez, Alejandro…[et al.]. Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis. Tuberculosis Research and Treatment No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-464552
American Medical Association (AMA)
Sanchez, Alejandro& Azen, Colleen G.& Jones, Brenda& Louie, Stan& Sattler, Fred. Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis. Tuberculosis Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-464552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464552