Ampelopsis Radix Protects Dopaminergic Neurons against 1-Methyl-4-phenylpyridinium1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Toxicity in Parkinson’s Disease Models In Vitro and In Vivo
Joint Authors
Shim, Jin Sup
Lee, Hyejung
Oh, Myung Sook
Park, Hanbyeol
Kim, Hyo Geun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ampelopsis Radix, the root of Ampelopsis japonica (Thunb.) Makino (Vitaceae), is a herbal medicine which has been widely used in East Asia.
The present study was done to explore whether the standardized extract of Ampelopsis Radix (AJW) protects dopaminergic neurons via antioxidant mechanisms in Parkinson’s disease (PD) models.
The effects of AJW on primary mesencephalic cultures stressed with 1-methyl-4-phenylpyridinium were investigated using tyrosine hydroxylase (TH) immunohistochemistry and reactive oxygen species measurement.
The eliminative effects of AJW on the 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) radicals were explored using colorimetric methods.
The effects of AJW on the mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were determined by pole test as well as TH and 8-hydroxydeoxyguanosine immunohistochemistry.
AJW protected dopaminergic neurons by inhibiting reactive oxygen species generation in vitro.
Moreover, AJW showed potent radical scavenging activities in vitro.
In the mouse PD model, AJW protected the dopaminergic neurons in the brain, leading to motor improvements.
AJW inhibited the MPTP-evoked accumulation of 8-hydroxydeoxyguanosine in the brain.
These data suggest that AJW has neuroprotective effects with antioxidant mechanisms in PD models.
American Psychological Association (APA)
Park, Hanbyeol& Shim, Jin Sup& Kim, Hyo Geun& Lee, Hyejung& Oh, Myung Sook. 2013. Ampelopsis Radix Protects Dopaminergic Neurons against 1-Methyl-4-phenylpyridinium1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Toxicity in Parkinson’s Disease Models In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-464563
Modern Language Association (MLA)
Park, Hanbyeol…[et al.]. Ampelopsis Radix Protects Dopaminergic Neurons against 1-Methyl-4-phenylpyridinium1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Toxicity in Parkinson’s Disease Models In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-464563
American Medical Association (AMA)
Park, Hanbyeol& Shim, Jin Sup& Kim, Hyo Geun& Lee, Hyejung& Oh, Myung Sook. Ampelopsis Radix Protects Dopaminergic Neurons against 1-Methyl-4-phenylpyridinium1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Toxicity in Parkinson’s Disease Models In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-464563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464563