Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators
Joint Authors
Knowlton, Anne A.
Blasi, Claudio
Kim, Eunjung
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The diabetes-atherosclerosis relationship remains to be fully defined.
Repeated prolonged hyperglycemia, increased ROS production and endothelial dysfunction are important factors.
One theory is that increased blood levels of heat shock protein (HSP)60 are proinflammatory, through activation of innate immunity, and contribute to the progression of vascular disease.
It was hypothesized that improvement of diabetes control in patients presenting with metabolic syndrome would lower HSP60, and anti-HSP60 antibody levels and decrease inflammatory markers.
Paired sera of 17 Italian patients, before and after intensive treatment, were assayed for cytokines, HSP60 and anti-HSP60 antibodies.
As expected, intensive treatment was associated with a decrease in HgbA1C (P<0.001) and BMI (P<0.001).
After treatment, there was a significant decrease in IL-6 (P<0.05).
HSP60 levels were before treatment −6.9+1.9, after treatment −7.1+2.0 ng/mL (P=ns).
Overall HSP60 concentrations were lower than published reports.
Anti-HSP60 antibody titers were high and did not decrease with treatment.
In conclusion, improvement of diabetic control did not alter HSP60 concentrations or antiHSP60 antibody titers, but led to a reduction of IL-6 levels.
American Psychological Association (APA)
Blasi, Claudio& Kim, Eunjung& Knowlton, Anne A.. 2012. Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-464568
Modern Language Association (MLA)
Blasi, Claudio…[et al.]. Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators. Autoimmune Diseases No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-464568
American Medical Association (AMA)
Blasi, Claudio& Kim, Eunjung& Knowlton, Anne A.. Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-464568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464568