Genetic Variability in Susceptibility to Occupational Respiratory Sensitization
Joint Authors
Johnson, Victor J.
Yucesoy, Berran
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Respiratory sensitization can be caused by a variety of substances at workplaces, and the health and economic burden linked to allergic respiratory diseases continues to increase.
Although the main factors that affect the onset of the symptoms are the types and intensity of allergen exposure, there is a wide range of interindividual variation in susceptibility to occupational/environmental sensitizers.
A number of gene variants have been reported to be associated with various occupational allergic respiratory diseases.
Examples of genes include, but are not limited to, genes involved in immune/inflammatory regulation, antioxidant defenses, and fibrotic processes.
Most of these variants act in combination with other genes and environmental factors to modify disease progression, severity, or resolution after exposure to allergens.
Therefore, understanding the role of genetic variability and the interaction between genetic and environmental/occupational factors provides new insights into disease etiology and may lead to the development of novel preventive and therapeutic strategies.
This paper will focus on the current state of knowledge regarding genetic influences on allergic respiratory diseases, with specific emphasis on diisocyanate-induced asthma and chronic beryllium disease.
American Psychological Association (APA)
Yucesoy, Berran& Johnson, Victor J.. 2011. Genetic Variability in Susceptibility to Occupational Respiratory Sensitization. Journal of Allergy،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-464581
Modern Language Association (MLA)
Yucesoy, Berran& Johnson, Victor J.. Genetic Variability in Susceptibility to Occupational Respiratory Sensitization. Journal of Allergy No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-464581
American Medical Association (AMA)
Yucesoy, Berran& Johnson, Victor J.. Genetic Variability in Susceptibility to Occupational Respiratory Sensitization. Journal of Allergy. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-464581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464581