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Hyaluronan Regulates Cell Behavior : A Potential Niche Matrix for Stem Cells
Joint Authors
Chen, Ying-Hui
Bittencourt, Vanessa Zaiatz
Solis, Mairim Alexandra
Huang, Lynn L. H.
Wong, Tzyy Yue
Lin, Yen-Cheng
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hyaluronan is a linear glycosaminoglycan that has received special attention in the last few decades due to its extraordinary physiological functions.
This highly viscous polysaccharide is not only a lubricator, but also a significant regulator of cellular behaviors during embryogenesis, morphogenesis, migration, proliferation, and drug resistance in many cell types, including stem cells.
Most hyaluronan functions require binding to its cellular receptors CD44, LYVE-1, HARE, layilin, and RHAMM.
After binding, proteins are recruited and messages are sent to alter cellular activities.
When low concentrations of hyaluronan are applied to stem cells, the proliferative activity is enhanced.
However, at high concentrations, stem cells acquire a dormant state and induce a multidrug resistance phenotype.
Due to the influence of hyaluronan on cells and tissue morphogenesis, with regards to cardiogenesis, chondrogenesis, osteogenesis, and neurogenesis, it is now been utilized as a biomaterial for tissue regeneration.
This paper summarizes the most important and recent findings regarding the regulation of hyaluronan in cells.
American Psychological Association (APA)
Solis, Mairim Alexandra& Chen, Ying-Hui& Wong, Tzyy Yue& Bittencourt, Vanessa Zaiatz& Lin, Yen-Cheng& Huang, Lynn L. H.. 2012. Hyaluronan Regulates Cell Behavior : A Potential Niche Matrix for Stem Cells. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-464605
Modern Language Association (MLA)
Solis, Mairim Alexandra…[et al.]. Hyaluronan Regulates Cell Behavior : A Potential Niche Matrix for Stem Cells. Biochemistry Research International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-464605
American Medical Association (AMA)
Solis, Mairim Alexandra& Chen, Ying-Hui& Wong, Tzyy Yue& Bittencourt, Vanessa Zaiatz& Lin, Yen-Cheng& Huang, Lynn L. H.. Hyaluronan Regulates Cell Behavior : A Potential Niche Matrix for Stem Cells. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-464605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464605