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Cardiac Hypertrophy and Fibrosis in the Metabolic Syndrome : A Role for Aldosterone and the Mineralocorticoid Receptor
Joint Authors
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Obesity and hypertension, major risk factors for the metabolic syndrome, render individuals susceptible to an increased risk of cardiovascular complications, such as adverse cardiac remodeling and heart failure.
There has been much investigation into the role that an increase in the renin-angiotensin-aldosterone system (RAAS) plays in the pathogenesis of metabolic syndrome and in particular, how aldosterone mediates left ventricular hypertrophy and increased cardiac fibrosis via its interaction with the mineralocorticoid receptor (MR).
Here, we review the pertinent findings that link obesity with elevated aldosterone and the development of cardiac hypertrophy and fibrosis associated with the metabolic syndrome.
These studies illustrate a complex cross-talk between adipose tissue, the heart, and the adrenal cortex.
Furthermore, we discuss findings from our laboratory that suggest that cardiac hypertrophy and fibrosis in the metabolic syndrome may involve cross-talk between aldosterone and adipokines (such as adiponectin).
American Psychological Association (APA)
Essick, Eric E.& Sam, Flora. 2011. Cardiac Hypertrophy and Fibrosis in the Metabolic Syndrome : A Role for Aldosterone and the Mineralocorticoid Receptor. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-464606
Modern Language Association (MLA)
Essick, Eric E.& Sam, Flora. Cardiac Hypertrophy and Fibrosis in the Metabolic Syndrome : A Role for Aldosterone and the Mineralocorticoid Receptor. International Journal of Hypertension No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-464606
American Medical Association (AMA)
Essick, Eric E.& Sam, Flora. Cardiac Hypertrophy and Fibrosis in the Metabolic Syndrome : A Role for Aldosterone and the Mineralocorticoid Receptor. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-464606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464606