Dendritic Cell-Based Graft Tolerance
Joint Authors
Kaouther, Mnasria
Ridha, Oueslati
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
It has recently been demonstrated that mouse and human dendritic cells (DCs) can produce IL-2 after activation.
However the role of the IL2/IL2R pathway in DC functions has not yet been fully elucidated.
The results presented in this study provide several new insights into the role of this pathway in DCs.
We report that stimulation of human monocyte-derived DCs with LPS strongly upregulated CD25 (α chain of the IL2R) expression.
In additon, by using a humanized monoclonal antibody against CD25, we demonstrated that the IL2 signalling in DC upregulated both IL-12 and γIFN production but decreased IL10 synthesis.
We also found that LPS-matured DCs produced IL2.
Taken together, these results suggest that IL-2 actively contributes to the DC activation through an autocrine pathway.
Furthermore, our results indicate that the IL2 pathway in DC is involved in the development of T-helper priming ability and in the upregulation of surface markers characteristic of a “mature” phenotype.
This study therefore provide new molecular clues regarding the split between these two phenomena and unravel new mechanisms of action of anti-CD25 monoclonal antibodies that may contribute to their action in several human immunological disorders such as autoimmune diseases and acute allograft rejection.
American Psychological Association (APA)
Kaouther, Mnasria& Ridha, Oueslati. 2011. Dendritic Cell-Based Graft Tolerance. ISRN Pharmacology،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-464617
Modern Language Association (MLA)
Kaouther, Mnasria& Ridha, Oueslati. Dendritic Cell-Based Graft Tolerance. ISRN Pharmacology No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-464617
American Medical Association (AMA)
Kaouther, Mnasria& Ridha, Oueslati. Dendritic Cell-Based Graft Tolerance. ISRN Pharmacology. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-464617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464617