Dendritic Cell-Based Graft Tolerance

Joint Authors

Kaouther, Mnasria
Ridha, Oueslati

Source

ISRN Pharmacology

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-04-10

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Pharmacy, Health & Medical Sciences
Pharmacology

Abstract EN

It has recently been demonstrated that mouse and human dendritic cells (DCs) can produce IL-2 after activation.

However the role of the IL2/IL2R pathway in DC functions has not yet been fully elucidated.

The results presented in this study provide several new insights into the role of this pathway in DCs.

We report that stimulation of human monocyte-derived DCs with LPS strongly upregulated CD25 (α chain of the IL2R) expression.

In additon, by using a humanized monoclonal antibody against CD25, we demonstrated that the IL2 signalling in DC upregulated both IL-12 and γIFN production but decreased IL10 synthesis.

We also found that LPS-matured DCs produced IL2.

Taken together, these results suggest that IL-2 actively contributes to the DC activation through an autocrine pathway.

Furthermore, our results indicate that the IL2 pathway in DC is involved in the development of T-helper priming ability and in the upregulation of surface markers characteristic of a “mature” phenotype.

This study therefore provide new molecular clues regarding the split between these two phenomena and unravel new mechanisms of action of anti-CD25 monoclonal antibodies that may contribute to their action in several human immunological disorders such as autoimmune diseases and acute allograft rejection.

American Psychological Association (APA)

Kaouther, Mnasria& Ridha, Oueslati. 2011. Dendritic Cell-Based Graft Tolerance. ISRN Pharmacology،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-464617

Modern Language Association (MLA)

Kaouther, Mnasria& Ridha, Oueslati. Dendritic Cell-Based Graft Tolerance. ISRN Pharmacology No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-464617

American Medical Association (AMA)

Kaouther, Mnasria& Ridha, Oueslati. Dendritic Cell-Based Graft Tolerance. ISRN Pharmacology. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-464617

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-464617