Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE
Joint Authors
Li, Xia
Lu, Zhi-Min
Shen, Min-Ning
Sun, Ling-Yun
Su, Ding-Lei
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-β, IL-10, BAFF, IL-6, IFN-α, IFN-γ, IL-17, and IL-23, play crucial pathogenic roles.
Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert different effects depending on specific local microenvironment.
They can also interact with each other, forming a complex network to maintain delicate immune homeostasis.
In this paper, we elaborate on the abnormal secretion and functions of these cytokines in SLE, analyze their potential pathogenic roles, and probe into the possibility of them being utilized as targets for therapy.
American Psychological Association (APA)
Su, Ding-Lei& Lu, Zhi-Min& Shen, Min-Ning& Li, Xia& Sun, Ling-Yun. 2012. Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-464619
Modern Language Association (MLA)
Su, Ding-Lei…[et al.]. Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-464619
American Medical Association (AMA)
Su, Ding-Lei& Lu, Zhi-Min& Shen, Min-Ning& Li, Xia& Sun, Ling-Yun. Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-464619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464619