Innate Immune Effectors in Mycobacterial Infection
Joint Authors
Takeda, Kiyoshi
Saiga, Hiroyuki
Shimada, Yosuke
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tuberculosis, which is caused by infection with Mycobacterium tuberculosis (Mtb), remains one of the major bacterial infections worldwide.
Host defense against Mtb is mediated by a combination of innate and adaptive immune responses.
In the last 15 years, the mechanisms for activation of innate immunity have been elucidated.
Toll-like receptors (TLRs) have been revealed to be critical for the recognition of pathogenic microorganisms including mycobacteria.
Subsequent studies further revealed that NOD-like receptors and C-type lectin receptors are responsible for the TLR-independent recognition of mycobacteria.
Several molecules, such as active vitamin D3, secretary leukocyte protease inhibitor, and lipocalin 2, all of which are induced by TLR stimulation, have been shown to direct innate immune responses to mycobacteria.
In addition, Irgm1-dependent autophagy has recently been demonstrated to eliminate intracellular mycobacteria.
Thus, our understanding of the mechanisms for the innate immune response to mycobacteria is developing.
American Psychological Association (APA)
Saiga, Hiroyuki& Shimada, Yosuke& Takeda, Kiyoshi. 2011. Innate Immune Effectors in Mycobacterial Infection. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-464659
Modern Language Association (MLA)
Saiga, Hiroyuki…[et al.]. Innate Immune Effectors in Mycobacterial Infection. Clinical and Developmental Immunology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-464659
American Medical Association (AMA)
Saiga, Hiroyuki& Shimada, Yosuke& Takeda, Kiyoshi. Innate Immune Effectors in Mycobacterial Infection. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-464659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464659