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A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System
Joint Authors
Adamson, Amy
LaJeunesse, Dennis
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Epstein-Barr virus, a member of the herpesvirus family, infects a large majority of the human population and is associated with several diseases, including cancer.
We have created Drosophila model systems to study the interactions between host cellular proteins and the Epstein-Barr virus (EBV) immediate-early genes BRLF1 and BZLF1.
BRLF1 and BZLF1 function as transcription factors for viral transcription and are also potent modifiers of host cell activity.
Here we have used our model systems to identify host cell genes whose proteins modulate BRLF1 and BZLF1 functions.
Via our GMR-R model system, we have found that BRLF1 expression results in overproliferation of fly tissue, unlike BZLF1, and does so through the interaction with known tumor suppressor genes.
Through an additional genetic screen, we have identified several Drosophila genes, with human homologs, that may offer further insights into the pathways that BRLF1 interacts with in order to promote EBV replication.
American Psychological Association (APA)
Adamson, Amy& LaJeunesse, Dennis. 2012. A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-464660
Modern Language Association (MLA)
Adamson, Amy& LaJeunesse, Dennis. A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-464660
American Medical Association (AMA)
Adamson, Amy& LaJeunesse, Dennis. A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-464660
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464660